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MedKoo Cat#: 414265 | Name: KP 736

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KP 736 has broad antmicrobial spectrum.

Chemical Structure

KP 736
KP 736
CAS#133686-28-9

Theoretical Analysis

MedKoo Cat#: 414265

Name: KP 736

CAS#: 133686-28-9

Chemical Formula: C42H34N16Na2O16S8

Exact Mass: 1319.9900

Molecular Weight: 1321.29

Elemental Analysis: C, 38.18; H, 2.59; N, 16.96; Na, 3.48; O, 19.37; S, 19.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
KP 736; KP736; KP-736
IUPAC/Chemical Name
5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(((1,4-dihydro-1,5-dihydroxy-4-oxo-2-pyridinyl)methoxy)imino)acetyl)amino)-8-oxo-3-((1,2,3-thiadiazol-5-ylthio)methyl)-, disodium salt, (6R-(6-alpha,7-beta(Z)))-
InChi Key
NXNGQVBDMDWMRD-UGLSBGGBSA-L
InChi Code
InChI=1S/2C21H18N8O8S4.2Na/c2*22-21-24-10(7-40-21)14(26-37-4-9-1-11(30)12(31)3-28(9)36)17(32)25-15-18(33)29-16(20(34)35)8(6-39-19(15)29)5-38-13-2-23-27-41-13;;/h2*1-3,7,15,19,31,36H,4-6H2,(H2,22,24)(H,25,32)(H,34,35);;/q;;2*+1/p-2/b2*26-14-;;/t2*15-,19-;;/m11../s1
SMILES Code
O=C(C(N12)=C(CSC3=CN=NS3)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OCC5=CC(C(O)=CN5O)=O)=O)C1=O)[O-].O=C(C(N67)=C(CSC8=CN=NS8)CS[C@]7([H])[C@H](NC(/C(C9=CSC(N)=N9)=N\OCC%10=CC(C(O)=CN%10O)=O)=O)C6=O)[O-].[Na+].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,321.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Tatsumi Y, Maejima T, Mitsuhashi S. Mechanism of tonB-dependent transport of KP-736, a 1,5-dihydroxy-4-pyridone-substituted cephalosporin, into Escherichia coli K-12 cells. Antimicrob Agents Chemother. 1995 Mar;39(3):613-9. doi: 10.1128/AAC.39.3.613. PMID: 7793861; PMCID: PMC162593. 2: Maejima T, Inoue M, Mitsuhashi S. In vitro antibacterial activity of KP-736, a new cephem antibiotic. Antimicrob Agents Chemother. 1991 Jan;35(1):104-10. doi: 10.1128/AAC.35.1.104. PMID: 2014964; PMCID: PMC244949. 3: Rabsch W, Methner U, Voigt W, Tschäpe H, Reissbrodt R, Williams PH. Role of receptor proteins for enterobactin and 2,3-dihydroxybenzoylserine in virulence of Salmonella enterica. Infect Immun. 2003 Dec;71(12):6953-61. doi: 10.1128/IAI.71.12.6953-6961.2003. PMID: 14638784; PMCID: PMC308886.

View History

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