2-MNG | CAS#2101538-28-5 | melanogenesis inhibitor

MedKoo Cat#: 128073 | Name: 2-MNG

Description:

WARNING: This product is for research use only, not for human or veterinary use.

2-MNG is an inhibitor for melanogenesis with an average IC50 of 49.5μM. 2-MNG alone significantly reduced immediate darkening and inhibited new melanin production when compared with vehicle, with higher performance at 1% than at 0.5%. 2-MNG at 0.5% in association with LHA and MSX showed significantly higher performance than 2-MNG 0.5% alone. 2-MNG at 0.5% and 1% showed significantly better performance than 4-n-BR.

Chemical Structure

2-MNG

CAS#2101538-28-5

Theoretical Analysis

MedKoo Cat#: 128073

Name: 2-MNG

CAS#: 2101538-28-5

Chemical Formula: C8H8N2O3S

Exact Mass: 212.0256

Molecular Weight: 212.22

Elemental Analysis: C, 45.28; H, 3.80; N, 13.20; O, 22.62; S, 15.11

Price and Availability

Size	Price	Availability
100mg	USD 750.00	2 Weeks
200mg	USD 1,250.00	2 Weeks
1g	USD 3,950.00	2 Weeks

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Related CAS #

No Data

Synonym

2-MNG; 2 MNG; 2MNG; 2-Mercaptonicotinoyl glycine

IUPAC/Chemical Name

(2-thioxo-1,2-dihydropyridine-3-carbonyl)glycine

InChi Key

LJJOEVWTSMQPDV-UHFFFAOYSA-N

InChi Code

InChI=1S/C8H8N2O3S/c11-6(12)4-10-7(13)5-2-1-3-9-8(5)14/h1-3H,4H2,(H,9,14)(H,10,13)(H,11,12)

SMILES Code

O=C(O)CNC(C1=CC=CNC1=S)=O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 212.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sextius P, Warrick E, Prévot-Guéguiniat A, Lereaux G, Boirre F, Baux L, Hassine SB, Qiu J, Huang X, Xu J, Grégoire S, Ito S, Wakamatsu K, Marat X. 2-Mercaptonicotinoyl glycine, a new potent melanogenesis inhibitor, exhibits a unique mode of action while preserving melanocyte integrity. Pigment Cell Melanoma Res. 2024 Jul;37(4):462-479. doi: 10.1111/pcmr.13168. Epub 2024 Apr 1. PMID: 38560773. 2: Dibdiakova K, Majercikova Z, Galanda T, Richterova R, Kolarovszki B, Racay P, Hatok J. Relationship between the Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Patients with Brain Tumors. Int J Mol Sci. 2024 Mar 1;25(5):2858. doi: 10.3390/ijms25052858. PMID: 38474106; PMCID: PMC10932124. 3: Muller B, Flament F, Jouni H, Sextius P, Tachon R, Wang Y, Wang H, Qiu H, Qiu J, Amar D, Delaunay C, Jablonski NG, Passeron T. A Bayesian network meta- analysis of 14 molecules inhibiting UV daylight-induced pigmentation. J Eur Acad Dermatol Venereol. 2024 Aug;38(8):1566-1574. doi: 10.1111/jdv.19910. Epub 2024 Mar 3. PMID: 38433524. 4: de Dormael R, Sextius P, Bourokba N, Mainguene E, Tachon R, Gaurav K, Jouni H, Bastien P, Diridollou S. 2-Mercaptonicotinoyl glycine prevents UV-induced skin darkening and delayed tanning in healthy subjects: A randomized controlled clinical study. J Cosmet Dermatol. 2024 May;23(5):1745-1752. doi: 10.1111/jocd.16200. Epub 2024 Feb 19. PMID: 38372022.