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MedKoo Cat#: 558381 | Name: WR23

Description:

WARNING: This product is for research use only, not for human or veterinary use.

WR23 is a phosphoinositide 3-kinase α (PI3Kα) inhibitor and a piperidinylquinoxaline derivative.

Chemical Structure

WR23
WR23
CAS#1350960-66-5

Theoretical Analysis

MedKoo Cat#: 558381

Name: WR23

CAS#: 1350960-66-5

Chemical Formula: C19H18BrN3O3S

Exact Mass: 447.0300

Molecular Weight: 448.33

Elemental Analysis: C, 50.90; H, 4.05; Br, 17.82; N, 9.37; O, 10.71; S, 7.15

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
WR23; WR-23; WR 23;
IUPAC/Chemical Name
1-[3-[(4-Bromophenyl)sulfonyl]-2-quinoxalinyl]-4-piperidinol
InChi Key
RGQAORGLDQFYED-UHFFFAOYSA-N
InChi Code
InChI=1S/C19H18BrN3O3S/c20-13-5-7-15(8-6-13)27(25,26)19-18(23-11-9-14(24)10-12-23)21-16-3-1-2-4-17(16)22-19/h1-8,14,24H,9-12H2
SMILES Code
OC1CCN(C2=NC3=CC=CC=C3N=C2S(=O)(C4=CC=C(Br)C=C4)=O)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 448.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Wu P, Su Y, Liu X, Yang B, He Q, Hu Y. Discovery of novel 2-piperidinol-3-(arylsulfonyl)quinoxalines as phosphoinositide 3-kinase α (PI3Kα) inhibitors. Bioorg Med Chem. 2012 May 1;20(9):2837-44. doi: 10.1016/j.bmc.2012.03.026. Epub 2012 Mar 17. PubMed PMID: 22480851. 2: Wu P, Su Y, Guan X, Liu X, Zhang J, Dong X, Huang W, Hu Y. Identification of novel piperazinylquinoxaline derivatives as potent phosphoinositide 3-kinase (PI3K) inhibitors. PLoS One. 2012;7(8):e43171. doi: 10.1371/journal.pone.0043171. Epub 2012 Aug 14. PubMed PMID: 22905224; PubMed Central PMCID: PMC3419191. 3: Kuopio T, Kankaanranta A, Jalava P, Kronqvist P, Kotkansalo T, Weber E, Collan Y. Cysteine proteinase inhibitor cystatin A in breast cancer. Cancer Res. 1998 Feb 1;58(3):432-6. PubMed PMID: 9458085.