RX-RA 85 | CAS#77749-81-6 | inhibitor

MedKoo Cat#: 585088 | Name: RX-RA 85

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RX-RA 85 is a pyrimido-pyrimidine derivative that is an inhibitor of platelet and tumor phosphodiesterase.

Chemical Structure

RX-RA 85

CAS#77749-81-6

Theoretical Analysis

MedKoo Cat#: 585088

Name: RX-RA 85

CAS#: 77749-81-6

Chemical Formula: C22H27N7OS2

Exact Mass: 469.1718

Molecular Weight: 469.63

Elemental Analysis: C, 56.27; H, 5.80; N, 20.88; O, 3.41; S, 13.65

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

RX-RA 85; RX-RA85; RX-RA-85

IUPAC/Chemical Name

Pyrimido(5,4-d)pyrimidine, 8-((2-phenylethyl)thio)-2-(1-piperazinyl)-4-(4-thiomorpholinyl)-, S-oxide

InChi Key

SFLXZGLWKMACEP-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H27N7OS2/c30-32-14-11-28(12-15-32)20-18-19(26-22(27-20)29-9-7-23-8-10-29)21(25-16-24-18)31-13-6-17-4-2-1-3-5-17/h1-5,16,23H,6-15H2

SMILES Code

O=S1CCN(C2=C(N=CN=C3SCCC4=CC=CC=C4)C3=NC(N5CCNCC5)=N2)CC1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 469.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lichtner RB, Hutchinson G, Hellmann K. The pyrimido-pyrimidine derivatives RA233 and RX-RA85 affect cell cycle distribution of two murine tumour cell lines. Eur J Cancer Clin Oncol. 1989 Jun;25(6):945-51. PubMed PMID: 2753057. 2: Lichtner RB, Nicolson GL. The pyrimido-pyrimidine derivatives RA 233 and RX-RA 85 affect growth and cytoskeletal organization of rat mammary adenocarcinoma cells. Eur J Cancer Clin Oncol. 1987 Sep;23(9):1269-75. PubMed PMID: 3678321. 3: Lichtner RB, Nicolson GL. Effects of the pyrimido-pyrimidine derivative RX-RA 85 on metastatic tumor cell-vascular endothelial cell interactions. Clin Exp Metastasis. 1987 Sep;5(3):219-31. PubMed PMID: 3652552. 4: Lichtner RB, Hutchinson G, Wedderburn N, Hellmann K. Antiplatelet pyrimido-pyrimidines and metastasis. Cancer Treat Rev. 1985 Dec;12(4):221-34. Review. PubMed PMID: 3009013. 5: Lichtner R, Wedderburn N. Enhancement of the immune response to sheep erythrocytes in mice by phosphodiesterase-inhibiting dipyridamole derivatives. J Immunopharmacol. 1984;6(1-2):43-55. PubMed PMID: 6088639.