MedKoo Cat#: 462545 | Name: KAN0438757
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3.

Chemical Structure

KAN0438757
KAN0438757
CAS#1451255-59-6

Theoretical Analysis

MedKoo Cat#: 462545

Name: KAN0438757

CAS#: 1451255-59-6

Chemical Formula: C21H18FNO7S

Exact Mass: 447.0788

Molecular Weight: 447.43

Elemental Analysis: C, 56.37; H, 4.06; F, 4.25; N, 3.13; O, 25.03; S, 7.17

Price and Availability

Size Price Availability Quantity
5mg USD 450.00 2 Weeks
10mg USD 850.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
KAN0438757; KAN-0438757; KAN 0438757
IUPAC/Chemical Name
2-hydroxyethyl 4-((5'-fluoro-2'-hydroxy-[1,1'-biphenyl])-3-sulfonamido)-2-hydroxybenzoate
InChi Key
QRDFCYMUXHUTCS-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H18FNO7S/c22-14-4-7-19(25)18(11-14)13-2-1-3-16(10-13)31(28,29)23-15-5-6-17(20(26)12-15)21(27)30-9-8-24/h1-7,10-12,23-26H,8-9H2
SMILES Code
O=C(OCCO)C1=CC=C(NS(=O)(C2=CC(C3=CC(F)=CC=C3O)=CC=C2)=O)C=C1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 447.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Gustafsson NMS, Färnegårdh K, Bonagas N, et al. Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination. Nat Commun. 2018;9(1):3872. Published 2018 Sep 24. doi:10.1038/s41467-018-06287-x