IC-1k is an HIV Capsid Modulator with High Ligand Efficiency. IC-1k exhibited an EC50 of 2.69 nM against HIV-1, being 393 times more potent than the positive control PF74. Notably, IC-1k emerged as the highest ligand efficiency (LE = 0.32) HIV CA modulator, surpassing that of the approved drug lenacapavir (LE = 0.21). IC-1k presents a promising lead compound for further optimization.
MedKoo Cat#: 128058
Name: IC-1k
CAS#: N/A
Chemical Formula: C27H22F2N4O3S
Exact Mass: 520.1381
Molecular Weight: 520.55
Elemental Analysis: C, 62.30; H, 4.26; F, 7.30; N, 10.76; O, 9.22; S, 6.16
The following data is based on the product molecular weight 520.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
