JBP923 |CAS# | Anti-inflammatory agent

MedKoo Cat#: 208029 | Name: JBP923

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JBP923 is a natural anti-inflammatory agent, showing potential for the treatment of inflammatory bowel disease (IBD).

Chemical Structure

JBP923

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 208029

Name: JBP923

CAS#: N/A

Chemical Formula: C8H14N2O5

Exact Mass: 218.0903

Molecular Weight: 218.21

Elemental Analysis: C, 44.03; H, 6.47; N, 12.84; O, 36.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JBP923; JBP 923; JBP-923

IUPAC/Chemical Name

((2S,4R)-4-hydroxypyrrolidine-2-carbonyl)-L-serine

InChi Key

UVSBYUFDCGZIMR-SRQIZXRXSA-N

InChi Code

InChI=1S/C8H14N2O5/c11-3-6(8(14)15)10-7(13)5-1-4(12)2-9-5/h4-6,9,11-12H,1-3H2,(H,10,13)(H,14,15)/t4-,5+,6+/m1/s1

SMILES Code

O=C(N[C@H](C(O)=O)CO)[C@H]1NC[C@H](O)C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 218.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Jiang Q, Xu Q, Wang Y, Li P, Zhang Y, Wang Y, Sun J, Zhang T, He Z. Modulation of Naturally Occurring Linear Dipeptide Chirality to Reduce the Affinity for Oligopeptide Transporter 1 and Increase Intestinal Stability for an Enhanced Colon-Targeting Effect in the Treatment of Inflammatory Bowel Disease: An Application of trans-4-l-Hydroxyprolyl-l-serine. J Med Chem. 2022 Mar 24;65(6):4565-4577. doi: 10.1021/acs.jmedchem.1c01276. Epub 2021 Nov 29. PMID: 34842428. 2: Jiang Q, Zhang J, Tong P, Gao Y, Lv Y, Wang C, Luo M, Sun M, Wang J, Feng Y, Cao L, Wang G, Wang Y, Kan Q, Zhang T, Wang Y, Liu K, Sun J, He Z. Bioactivatable Pseudotripeptidization of Cyclic Dipeptides To Increase the Affinity toward Oligopeptide Transporter 1 for Enhanced Oral Absorption: An Application to Cyclo(l-Hyp-l-Ser) (JBP485). J Med Chem. 2019 Sep 12;62(17):7708-7721. doi: 10.1021/acs.jmedchem.9b00358. Epub 2019 Sep 3. PMID: 31393124. 3: Guo X, Meng Q, Liu Q, Wang C, Huo X, Zhang Z, Kaku T, Liu K. Simultaneous determination of three dipeptides (JBP485, Gly-Sar and JBP923) in the cell lysates by liquid chromatography-tandem mass spectrometry: application to identify the function of the PEPT1 transfected cell. Biomed Chromatogr. 2014 Dec;28(12):1839-45. doi: 10.1002/bmc.3228. Epub 2014 Jun 6. PMID: 24903899. 4: Liu Z, Wang C, Liu Q, Meng Q, Cang J, Mei L, Kaku T, Liu K. Uptake, transport and regulation of JBP485 by PEPT1 in vitro and in vivo. Peptides. 2011 Apr;32(4):747-54. doi: 10.1016/j.peptides.2011.01.019. Epub 2011 Jan 22. PMID: 21262302. 5: Cang J, Zhang J, Wang C, Liu Q, Meng Q, Wang D, Sugiyama Y, Tsuji A, Kaku T, Liu K. Pharmacokinetics and mechanism of intestinal absorption of JBP485 in rats. Drug Metab Pharmacokinet. 2010;25(5):500-7. doi: 10.2133/dmpk.dmpk-10-rg-045. Epub 2010 Sep 22. PMID: 20877133. 6: Liu KX, Kato Y, Kaku TI, Santa T, Imai K, Yagi A, Ishizu T, Sugiyama Y. Hydroxyprolylserine derivatives JBP923 and JBP485 exhibit the antihepatitis activities after gastrointestinal absorption in rats. J Pharmacol Exp Ther. 2000 Aug;294(2):510-5. PMID: 10900226.