VX 759 | CAS#478025-29-5 | NS5B Inhibitor

MedKoo Cat#: 529405 | Name: VX 759

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VX 759 is a nonstructural protein 5B (NS5B) inhibitor potentially for the treatment of HCV infection.

Chemical Structure

VX 759

CAS#478025-29-5

Theoretical Analysis

MedKoo Cat#: 529405

Name: VX 759

CAS#: 478025-29-5

Chemical Formula: C22H27NO3S

Exact Mass: 385.1712

Molecular Weight: 385.52

Elemental Analysis: C, 68.54; H, 7.06; N, 3.63; O, 12.45; S, 8.32

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

VX-759; BCH-27759; VCH-759; VX759; BCH27759; VCH759; VX 759; BCH 27759; VCH 759; NNI-1

IUPAC/Chemical Name

3-(N-isopropyl-4-methylcyclohexane-1-carboxamido)-5-phenylthiophene-2-carboxylic acid

InChi Key

RZXQBIKGWSLVEK-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H27NO3S/c1-14(2)23(21(24)17-11-9-15(3)10-12-17)18-13-19(27-20(18)22(25)26)16-7-5-4-6-8-16/h4-8,13-15,17H,9-12H2,1-3H3,(H,25,26)

SMILES Code

O=C(C1=C(N(C(C2CCC(C)CC2)=O)C(C)C)C=C(C3=CC=CC=C3)S1)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 385.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Snider TH, Wilhelm CM, Babin MC, Platoff GE Jr, Yeung DT. Assessing the therapeutic efficacy of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig. J Toxicol Sci. 2015 Dec;40(6):759-75. doi: 10.2131/jts.40.759. PubMed PMID: 26558457; PubMed Central PMCID: PMC4747113. 2: De Clercq E. Current race in the development of DAAs (direct-acting antivirals) against HCV. Biochem Pharmacol. 2014 Jun 15;89(4):441-52. doi: 10.1016/j.bcp.2014.04.005. PubMed PMID: 24735613. 3: Xin L, Lanz B, Lei H, Gruetter R. Assessment of metabolic fluxes in the mouse brain in vivo using 1H-[13C] NMR spectroscopy at 14.1 Tesla. J Cereb Blood Flow Metab. 2015 May;35(5):759-65. doi: 10.1038/jcbfm.2014.251. PubMed PMID: 25605294; PubMed Central PMCID: PMC4420852. 4: Godzik P, Komorowski M, Cielecka-Kuszyk J, Madaliński K. [Inhibitors of hepatitis C virus--current standards and status of investigations]. Przegl Epidemiol. 2010;64(4):473-8. Polish. PubMed PMID: 21473060. 5: Egelman EH. Homomorphous hexameric helicases: tales from the ring cycle. Structure. 1996 Jul 15;4(7):759-62. Review. PubMed PMID: 8805564.