Axitirome, also known as CGS26214, is a highly selective thyromimetic and a synthetic cholesterol-lowering agent (HMG CoA reductase inhibitor) shown to be active in the rat, dog and monkey. CGS 26214 is a racemic compound, which is consisted of two equipotent chiral components CGS 28934(-) and CGS 28935(+). CGS 26214, virtually devoid of cardiovascular effects, has potent cholesterol-lowering activity in several models, reduces post-prandial response to a fat load in rats and markedly lowers Lp(a) concentrations in monkeys.
MedKoo Cat#: 593109
Name: Axitirome
CAS#: 156740-57-7
Chemical Formula: C25H24FNO6
Exact Mass: 453.1588
Molecular Weight: 453.47
Elemental Analysis: C, 66.22; H, 5.33; F, 4.19; N, 3.09; O, 21.17
The following data is based on the product molecular weight 453.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
