R-137696 | CAS#695185-73-0 | serotonin-1A (5-HT(1A)) receptor agonist

MedKoo Cat#: 145181 | Name: R-137696

Description:

WARNING: This product is for research use only, not for human or veterinary use.

R-137696 is a serotonin-1A (5-HT(1A)) receptor agonist. R-137696 is known to relax the proximal stomach in man. A 4-week administration of the fundus-relaxing 5-HT(1A) agonist R-137696 failed to significantly improve symptoms, VH or gastric accommodation compared to placebo.

Chemical Structure

R-137696

CAS#695185-73-0

Theoretical Analysis

MedKoo Cat#: 145181

Name: R-137696

CAS#: 695185-73-0

Chemical Formula: C17H23N3O2

Exact Mass: 301.1790

Molecular Weight: 301.39

Elemental Analysis: C, 67.75; H, 7.69; N, 13.94; O, 10.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

R-137696; R137696; R 137696;

IUPAC/Chemical Name

1-(3-(((2H-chromen-2-yl)methyl)amino)propyl)tetrahydropyrimidin-2(1H)-one

InChi Key

WVFDYQCBLOVCJP-UHFFFAOYSA-N

InChi Code

1S/C17H23N3O2/c21-17-19-10-4-12-20(17)11-3-9-18-13-15-8-7-14-5-1-2-6-16(14)22-15/h1-2,5-8,15,18H,3-4,9-13H2,(H,19,21)

SMILES Code

O=C1NCCCN1CCCNCC2OC3=CC=CC=C3C=C2

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 301.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Tack J, Van Den Elzen B, Tytgat G, Wajs E, Van Nueten L, De Ridder F, Boeckxstaens G. A placebo-controlled trial of the 5-HT1A agonist R-137696 on symptoms, visceral hypersensitivity and on impaired accommodation in functional dyspepsia. Neurogastroenterol Motil. 2009 Jun;21(6):619-26, e23-4. doi: 10.1111/j.1365-2982.2008.01260.x. Epub 2009 Feb 11. PMID: 19220756.