Ezurpimtrostat, also known as GNS-561, is a PPT1 and SLCT inhibitor. Ezurpimtrostat targets and inhibits the activity of PPT1 and induces lysosomal disruption, which results in the inhibition of autophagy and the induction of apoptosis via caspase activation. This may inhibit tumor cell proliferation and tumor growth. PPT1, a lysosomal thioesterase that plays an important role in lysosomal function and autophagy, is overexpressed in certain cancers.
MedKoo Cat#: 124483
Name: Ezurpimtrostat HCl
CAS#: 1914148-73-4 (HCl)
Chemical Formula: C25H32Cl2N4
Exact Mass: 458.2004
Molecular Weight: 459.46
Elemental Analysis: C, 65.35; H, 7.02; Cl, 15.43; N, 12.19
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8.3 | 18.13 |
The following data is based on the product molecular weight 459.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
