Ocaphane | Antitumor | CAS#3734-80-3

MedKoo Cat#: 525772 | Name: Ocaphane

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ocaphane is a strong antitumor agent used on a number of animal tumors such as Brown-Pearce carcinoma. In clinical trials, it was found to be effective in treating patients with malignant pleural effusion and cancer of the head and neck. However, it was fairly toxic to hemopoietic organs.

Chemical Structure

Ocaphane

CAS#3734-80-3

Theoretical Analysis

MedKoo Cat#: 525772

Name: Ocaphane

CAS#: 3734-80-3

Chemical Formula: C14H20Cl2N2O2

Exact Mass: 318.0902

Molecular Weight: 319.23

Elemental Analysis: C, 52.67; H, 6.31; Cl, 22.21; N, 8.78; O, 10.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

AT581; AT 581; AT-581; Ocaphane

IUPAC/Chemical Name

(S)-2-amino-3-(2-((bis(2-chloroethyl)amino)methyl)phenyl)propanoic acid

InChi Key

IKQQYIXDSFFRTE-ZDUSSCGKSA-N

InChi Code

InChI=1S/C14H20Cl2N2O2/c15-5-7-18(8-6-16)10-12-4-2-1-3-11(12)9-13(17)14(19)20/h1-4,13H,5-10,17H2,(H,19,20)/t13-/m0/s1

SMILES Code

N[C@@H](CC1=CC=CC=C1CN(CCCl)CCCl)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 319.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Su-yin C, Hsiu-fang Y, Pin H. Absorption, distribution and excretion of C14-AT-581 in animals. Chin Med J (Engl). 1976 Nov;2(6):441-4. PubMed PMID: 828876. 2: Yang JL, Lu FL, Wang LJ, Xu B. [The therapeutic effect of O-[bis-(2-chloroethyl)-aminomethyl]-phenylalanine dihydrochloride (ocaphane, AT-581) on intracerebral growth of Brown-Pearce carcinoma in rabbits (author's transl)]. Yao Xue Xue Bao. 1981 Dec;16(12):881-5. Chinese. PubMed PMID: 7340381. 3: Yang JL, Hsu B. [Studies on the combined chemotherapy of o-[bis-(2-chloroethyl)-aminomethyl]-phenylalanine dihydrochloride (AT-581) and operation in the treatment of Brown-Pearce carcinoma in the rabbit]. Yao Xue Xue Bao. 1966 Feb;13(2):113-8. Chinese. PubMed PMID: 5952402. 4: YANG JL, HSU B. [THERAPEUTIC EFFECT OF AT-581 ON THE BROWN-PEARCE CARCINOMA IN RABBITS AND ITS INFLUENCE ON MITOSIS OF THE TUMOR CELLS]. Yao Xue Xue Bao. 1965 Apr;12:235-41. Chinese. PubMed PMID: 14321745.