IACS-8968 | CAS#2144425-14-7 | IDO/TDO Inhibitor

MedKoo Cat#: 462484 | Name: IACS-8968

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

IACS-8968 is a dual IDO and TDO inhibitor.

Chemical Structure

IACS-8968

CAS#2144425-14-7

Theoretical Analysis

MedKoo Cat#: 462484

Name: IACS-8968

CAS#: 2144425-14-7

Chemical Formula: C17H18F3N5O2

Exact Mass: 381.1413

Molecular Weight: 381.36

Elemental Analysis: C, 53.54; H, 4.76; F, 14.95; N, 18.36; O, 8.39

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 450.00	2 Weeks
5mg	USD 1,250.00	2 Weeks

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Related CAS #

No Data

Synonym

IACS-8968; IACS 8968; IACS8968

IUPAC/Chemical Name

6,6-dimethyl-8-(7-(trifluoromethyl)imidazo[1,5-a]pyridin-5-yl)-1,3,8-triazaspiro[4.5]decane-2,4-dione

InChi Key

UBMTZODMRPHSBC-UHFFFAOYSA-N

InChi Code

InChI=1S/C17H18F3N5O2/c1-15(2)8-24(4-3-16(15)13(26)22-14(27)23-16)12-6-10(17(18,19)20)5-11-7-21-9-25(11)12/h5-7,9H,3-4,8H2,1-2H3,(H2,22,23,26,27)

SMILES Code

O=C(NC12C(C)(CN(CC1)C3=CC(C(F)(F)F)=CC4=CN=CN34)C)NC2=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

IACS-8968 (IDO/TDO Inhibitor) is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	50.0	131.11

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 381.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.