MedKoo Cat#: 127888 | Name: D228

Description:

WARNING: This product is for research use only, not for human or veterinary use.

D228 is a Furanone Glycoside for the Treatment of Inflammatory Bowel Disease. D228 could be considered as a prodrug and metabolized to intermediate Phoenicein. Additionally, D228 demonstrated good and balanced profiles of safety and efficacy both in vitro and in vivo.

Chemical Structure

D228
D228
CAS#N/A

Theoretical Analysis

MedKoo Cat#: 127888

Name: D228

CAS#: N/A

Chemical Formula: C22H28O12

Exact Mass: 484.1581

Molecular Weight: 484.45

Elemental Analysis: C, 54.54; H, 5.83; O, 39.63

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
D228; D-228; D 228
IUPAC/Chemical Name
(2R,3R,4S,5R,6S)-2-(acetoxymethyl)-6-((2-methyl-4-oxo-5-(propan-2-ylidene)-4,5-dihydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate
InChi Key
GLNKLSQINQQSFI-OIJANJFZSA-N
InChi Code
InChI=1S/C22H28O12/c1-9(2)17-16(27)18(10(3)29-17)34-22-21(32-14(7)26)20(31-13(6)25)19(30-12(5)24)15(33-22)8-28-11(4)23/h15,19-22H,8H2,1-7H3/t15-,19?,20?,21?,22+/m1/s1
SMILES Code
O=C1C(O[C@H]2[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O2)=C(C)O/C1=C(C)\C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 484.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Tang ML, Xiong XY, Zhang H, Wang YZ, Cheng RQ, Zuo J, Jin L, Lin ZM, Chang J. From Hit to Lead: Discovery of First-In-Class Furanone Glycoside D228 Derived from Chimonanthus salicifolius for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2024 Sep 19. doi: 10.1021/acs.jmedchem.4c00591. Epub ahead of print. PMID: 39298383.