Kalopanaxsaponin B | CAS#14216-03-6 | Ameliorates TNBS-Induced Colitis

MedKoo Cat#: 592363 | Name: Kalopanaxsaponin B

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WARNING: This product is for research use only, not for human or veterinary use.

Kalopanaxsaponin B Ameliorates TNBS-Induced Colitis in Mice.

Chemical Structure

Kalopanaxsaponin B

CAS#14216-03-6

Theoretical Analysis

MedKoo Cat#: 592363

Name: Kalopanaxsaponin B

CAS#: 14216-03-6

Chemical Formula: C59H96O56

Exact Mass: 1220.9200

Molecular Weight: 1221.39

Elemental Analysis: C, 58.02; H, 7.92; O, 34.06

Price and Availability

Size	Price	Availability	Quantity
50mg	USD 350.00	2 Weeks
100mg	USD 550.00	2 Weeks

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Synonym

Kalopanaxsaponin B; Glycoside L-H2; Hederacoside C; Hederoside H1; Akeboside Sth; Tauroside H2; Pericarsaponin Pk; Tauroside St-H2

IUPAC/Chemical Name

(2S,3R,4S,5S,6R)-6-((((2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)methyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl (4aS,6aS,6bR,8aR,9R,10S,12aR,12bR,14bS)-10-(((2S,3R,4S,5S)-4,5-dihydroxy-3-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-9-(hydroxymethyl)-2,2,6a,6b,9,12a-hexamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylate

InChi Key

RYHDIBJJJRNDSX-MCGLQMIESA-N

InChi Code

InChI=1S/C59H96O26/c1-24-34(63)38(67)42(71)49(78-24)83-46-29(20-60)80-48(45(74)41(46)70)77-22-30-37(66)40(69)44(73)51(81-30)85-53(75)59-17-15-54(3,4)19-27(59)26-9-10-32-55(5)13-12-33(56(6,23-61)31(55)11-14-58(32,8)57(26,7)16-18-59)82-52-47(36(65)28(62)21-76-52)84-50-43(72)39(68)35(64)25(2)79-50/h9,24-25,27-52,60-74H,10-23H2,1-8H3/t24-,25-,27-,28-,29+,30+,31+,32+,33-,34-,35-,36-,37+,38+,39+,40-,41+,42+,43+,44+,45+,46+,47+,48+,49-,50-,51-,52-,55-,56-,57+,58+,59-/m0/s1

SMILES Code

O=C([C@]12CCC(C)(C)C[C@@]1([H])C3=CC[C@]4([H])[C@@]5(C)CC[C@H](O[C@@H]6OC[C@H](O)[C@H](O)[C@H]6O[C@@H]7O[C@@H](C)[C@H](O)[C@@H](O)[C@H]7O)[C@@](C)(CO)[C@]5([H])CC[C@@]4(C)[C@]3(C)CC2)O[C@@H]8O[C@H](CO[C@@H]9O[C@H](CO)[C@@H](O[C@@H]%10O[C@@H](C)[C@H](O)[C@@H](O)[C@H]%10O)[C@H](O)[C@H]9O)[C@@H](O)[C@H](O)[C@H]8O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,221.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lu XR, Liu S, Wang MY, Gong MX, Wang ZM, Chen XQ. [Triterpenoids from Stauntonia obovatifoliola Hayata subsp. intermedia stems]. Zhongguo Zhong Yao Za Zhi. 2014 Dec;39(23):4629-36. Chinese. PubMed PMID: 25911814. 2: Jeong JJ, Jang SE, Joh EH, Han MJ, Kim DH. Kalopanaxsaponin B Ameliorates TNBS-Induced Colitis in Mice. Biomol Ther (Seoul). 2012 Sep;20(5):457-62. doi: 10.4062/biomolther.2012.20.5.457. PubMed PMID: 24009834; PubMed Central PMCID: PMC3762277. 3: Joh EH, Jeong JJ, Kim DH. Kalopanaxsaponin B inhibits LPS-induced inflammation by inhibiting IRAK1 Kinase. Cell Immunol. 2012 Sep;279(1):103-8. doi: 10.1016/j.cellimm.2012.10.001. Epub 2012 Oct 12. PubMed PMID: 23117333. 4: Joh EH, Lee IA, Kim DH. Kalopanaxsaponins A and B isolated from Kalopanax pictus ameliorate memory deficits in mice. Phytother Res. 2012 Apr;26(4):546-51. doi: 10.1002/ptr.3596. Epub 2011 Sep 16. PubMed PMID: 21928370. 5: Choi J, Huh K, Kim SH, Lee KT, Park HJ, Han YN. Antinociceptive and anti-rheumatoidal effects of Kalopanax pictus extract and its saponin components in experimental animals. J Ethnopharmacol. 2002 Feb;79(2):199-204. PubMed PMID: 11801382. 6: Choi J, Huh K, Kim SH, Lee KT, Lee HK, Park HJ. Kalopanaxsaponin A from Kalopanax pictus, a potent antioxidant in the rheumatoidal rat treated with Freund's complete adjuvant reagent. J Ethnopharmacol. 2002 Jan;79(1):113-8. PubMed PMID: 11744304. 7: Lee KT, Sohn IC, Park HJ, Kim DW, Jung GO, Park KY. Essential moiety for antimutagenic and cytotoxic activity of hederagenin monodesmosides and bisdesmosides isolated from the stem bark of Kalopanax pictus. Planta Med. 2000 May;66(4):329-32. PubMed PMID: 10865448. 8: Kim DH, Yu KW, Bae EA, Park HJ, Choi JW. Metabolism of kalopanaxsaponin B and H by human intestinal bacteria and antidiabetic activity of their metabolites. Biol Pharm Bull. 1998 Apr;21(4):360-5. PubMed PMID: 9586573. 9: Cho SH, Hahn DR. Triterpenoidal saponins from the bark of Kalopanax pictum var. typicum. Arch Pharm Res. 1991 Mar;14(1):19-24. PubMed PMID: 10319115. 10: Sun WJ, Zhang DK, Sha ZF, Zhang HL, Zhang XL. [Studies on the saponin constituents of Kalopanax septemlobus (Thunb.) koidz]. Yao Xue Xue Bao. 1990;25(1):29-34. Chinese. PubMed PMID: 2363354.