U 72745G | CAS#378-61-0 | antagonist

MedKoo Cat#: 585310 | Name: U 72745G

Description:

WARNING: This product is for research use only, not for human or veterinary use.

U 72745G is an angiogenesis factor antagonist.

Chemical Structure

U 72745G

CAS#378-61-0

Theoretical Analysis

MedKoo Cat#: 585310

Name: U 72745G

CAS#: 378-61-0

Chemical Formula: C22H29FO4

Exact Mass: 376.2050

Molecular Weight: 376.47

Elemental Analysis: C, 70.19; H, 7.76; F, 5.05; O, 17.00

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

U 72745G; U-42129; U-72,745G; U-72745G

IUPAC/Chemical Name

Pregna-4,9(11)-diene-3,20-dione, 6-fluoro-17,21-dihydroxy-16-methyl-, (6alpha,16alpha)-

InChi Key

MUEOUHRWNRABSW-XUOSUNSOSA-N

InChi Code

InChI=1S/C22H29FO4/c1-12-8-16-14-10-18(23)17-9-13(25)4-6-20(17,2)15(14)5-7-21(16,3)22(12,27)19(26)11-24/h5,9,12,14,16,18,24,27H,4,6-8,10-11H2,1-3H3/t12-,14-,16+,18+,20-,21+,22+/m1/s1

SMILES Code

C[C@@]12[C@](C(CO)=O)(O)[C@H](C)C[C@@]1([H])[C@]3([H])C[C@H](F)C4=CC(CC[C@]4(C)C3=CC2)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 376.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Pepper MS, Vassalli JD, Wilks JW, Schweigerer L, Orci L, Montesano R. Modulation of bovine microvascular endothelial cell proteolytic properties by inhibitors of angiogenesis. J Cell Biochem. 1994 Aug;55(4):419-34. PubMed PMID: 7525617. 2: Li WW, Casey R, Gonzalez EM, Folkman J. Angiostatic steroids potentiated by sulfated cyclodextrins inhibit corneal neovascularization. Invest Ophthalmol Vis Sci. 1991 Oct;32(11):2898-905. PubMed PMID: 1917393.