MedKoo Cat#: 462088 | Name: JBJ-03-142-02
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

JBJ-03-142-02 is a highly potent EGFR and ErbB2 inhibitor that inhibits wild type and mutated receptors.

Chemical Structure

JBJ-03-142-02
JBJ-03-142-02
CAS#2068806-31-3

Theoretical Analysis

MedKoo Cat#: 462088

Name: JBJ-03-142-02

CAS#: 2068806-31-3

Chemical Formula: C25H22FN7O3

Exact Mass: 487.1768

Molecular Weight: 487.50

Elemental Analysis: C, 61.60; H, 4.55; F, 3.90; N, 20.11; O, 9.85

Price and Availability

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10mg USD 550.00 2 Weeks
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Related CAS #
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Synonym
JBJ-03-142-02
IUPAC/Chemical Name
(4-Fluorophenyl)methyl N-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-N-[3-[(1-oxo-2-propen-1-yl)amino]phenyl]carbamate
InChi Key
IFRXGTCPIGRGHP-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H22FN7O3/c1-3-23(34)29-19-5-4-6-21(13-19)33(25(35)36-16-17-7-9-18(26)10-8-17)22-11-12-27-24(31-22)30-20-14-28-32(2)15-20/h3-15H,1,16H2,2H3,(H,29,34)(H,27,30,31)
SMILES Code
O=C(OCC1=CC=C(F)C=C1)N(C2=NC(NC3=CN(C)N=C3)=NC=C2)C4=CC=CC(NC(C=C)=O)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 487.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor Dr. Jaebong Jang, Dr. Jieun Son, Dr. Eunyoung Park, Dr. Takayuki Kosaka, Dr. Jamie A. Saxon, Dr. Dries J. H. De Clercq, Dr. Hwan Geun Choi, Dr. Junko Tanizaki, Dr. Michael J. Eck, Dr. Pasi A. Jänne, Dr. Nathanael S. Gray Angew Chem Int Ed Engl. Author manuscript; available in PMC 2018 Sep 3.Published in final edited form as: Angew Chem Int Ed Engl. 2018 Sep 3; 57(36): 11629 11633. Published online 2018 Aug 3. doi: 10.1002/anie.201805187 PMCID: PMC6118895