Uridine Triacetate | Vistonuridine | CAS#4105-38-8

MedKoo Cat#: 203090 | Name: Uridine triacetate

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Uridine triacetate is a drug used in the treatment of hereditary orotic aciduria and to treat patients following an overdose of chemotherapy drugs 5-fluorouracil or capecitabine, or in patients exhibiting early-onset, severe or life-threatening toxicity affecting the cardiac or central nervous system, and/or early-onset, unusually severe adverse reactions (e.g., gastrointestinal toxicity and/or neutropenia) within 96 hours following the end of 5-fluorouracil or capecitabine administration. Uridine triacetate was granted breakthrough therapy designation by FDA in 2015. Uridine triacetate is a prodrug of uridine.

Chemical Structure

Uridine triacetate

CAS#4105-38-8

Theoretical Analysis

MedKoo Cat#: 203090

Name: Uridine triacetate

CAS#: 4105-38-8

Chemical Formula: C15H18N2O9

Exact Mass: 370.1012

Molecular Weight: 370.31

Elemental Analysis: C, 48.65; H, 4.90; N, 7.56; O, 38.88

Price and Availability

Size	Price	Availability
500mg	USD 150.00	Ready to ship
1g	USD 250.00	Ready to ship
2g	USD 350.00	Ready to ship
5g	USD 450.00	Ready to ship
10g	USD 650.00	Ready to ship
20g	USD 1,050.00	Ready to ship

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Related CAS #

No Data

Synonym

PN401; PN 401; PN-401; RG 2133; RG2133; RG-2133; Tri-O-acetyluridine; Triacetyluridine; Vistogard; Vistonuridine; Xuriden;

IUPAC/Chemical Name

(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate

InChi Key

AUFUWRKPQLGTGF-FMKGYKFTSA-N

InChi Code

InChI=1S/C15H18N2O9/c1-7(18)23-6-10-12(24-8(2)19)13(25-9(3)20)14(26-10)17-5-4-11(21)16-15(17)22/h4-5,10,12-14H,6H2,1-3H3,(H,16,21,22)/t10-,12-,13-,14-/m1/s1

SMILES Code

O=C(C=CN1[C@H]2[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O2)NC1=O

Appearance

White solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Solubility

Soluble in DMSO, not in water

Shelf Life

>5 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

According to news published in 21 May 2010, uridine triacetate has further demonstrated its life-saving potential in treating patients overexposed to the widely used cancer chemotherapy 5-fluorouracil (5-FU), according to clinical data to be presented June 7 at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago. see http://www.medicalnewstoday.com/articles/189546.php. Wellstat Releases Investigational Drug Uridine Triacetate Clinical Results By PBR Staff Writer Published 21 May 2010 Wellstat Therapeutics has released clinical results of its investigational drug Uridine triacetate for treating patients overexposed to the widely used cancer chemotherapy 5-fluorouracil (5-FU). Wellstat Therapeutics said that while no antidote for 5-FU overexposure has been approved by regulatory authorities, Uridine triacetate (formerly known as vistonuridine) has been made available to physicians for emergency use. Wellstat Therapeutics' trial was made on 37 cases of 5-FU overexposure, all of them treated with Uridine triacetate. In all of these cases, the patients recovered from the overexposure, even though a fatal outcome for at least 27 of them would have been predicted by the dose and rate of 5-FU administration. In one extreme case, the patient survived after receiving a 5-FU dose 10 times higher than intended (10,000mg in three hours instead of 1,000mg in one hour). Reportedly, in all cases, the emergency treatment commenced as rapidly as possible after 5-FU overexposure (within 8 to 96 hours), depending on the timing of the request to Wellstat and the location of the treatment site. Michael Bamat, vice president of research and development at Wellstat, said: Â“Since our first report on uridine triacetate at ASCO in 2009, the number of patients treated with this investigational antidote has more than doubled.Â”

Certificate of Analysis

View CoA: current batch, Lot#TC70424

Safety Data Sheet (SDS)

View Safety Data Sheet (SDS)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 370.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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