Y27632 is a selective ROCK inhibitor, which inhibits ET-1-induced increases in natriuretic peptide production, cell size, protein synthesis, and myofibrillar organization. Y27632 prevents dimethylnitrosamine-induced hepatic fibrosis in rats, increases apoptosis and disrupts the actin cortical mat in embryonic avian corneal epithelium, affects initial heart myofibrillogenesis in cultured chick blastoderm, promotes the proliferation and cell cycle progression of cultured astrocyte from spinal cord.
MedKoo Cat#: 574938
Name: Y27632 HCl hydrate
CAS#: 331752-47-7 (HCl hydrate)
Chemical Formula: C14H25Cl2N3O2
Exact Mass: 0.0000
Molecular Weight: 338.27
Elemental Analysis: C, 49.71; H, 7.45; Cl, 20.96; N, 12.42; O, 9.46
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| water | 14.0 | 41.39 |
The following data is based on the product molecular weight 338.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
