MedKoo Cat#: 530579 | Name: Galicaftor free acid
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Galicaftor, also known as ABBV-2222 and GLPG2222, is a CFTR corrector being studied for the treatment of cystic fibrosis (CF).

Chemical Structure

Galicaftor free acid
Galicaftor free acid
CAS#1918143-53-9 (free acid)

Theoretical Analysis

MedKoo Cat#: 530579

Name: Galicaftor free acid

CAS#: 1918143-53-9 (free acid)

Chemical Formula: C28H21F4NO7

Exact Mass: 559.1254

Molecular Weight: 559.47

Elemental Analysis: C, 60.11; H, 3.78; F, 13.58; N, 2.50; O, 20.02

Price and Availability

Size Price Availability Quantity
10mg USD 450.00 2 Weeks
25mg USD 750.00 2 Weeks
50mg USD 1,250.00 2 Weeks
100mg USD 2,150.00 2 Weeks
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Synonym
ABBV-2222; ABBV 2222; ABBV2222; GLPG2222; GLPG-2222; GLPG 2222; Galicaftor;
IUPAC/Chemical Name
4-((2R,4R)-4-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-7-(difluoromethoxy)chroman-2-yl)benzoic acid
InChi Key
QVDYQHXNAQHIKH-TZIWHRDSSA-N
InChi Code
InChI=1S/C28H21F4NO7/c29-26(30)37-17-6-7-18-19(13-21(38-22(18)12-17)14-1-3-15(4-2-14)24(34)35)33-25(36)27(9-10-27)16-5-8-20-23(11-16)40-28(31,32)39-20/h1-8,11-12,19,21,26H,9-10,13H2,(H,33,36)(H,34,35)/t19-,21-/m1/s1
SMILES Code
FC(F)OC1=CC=C2C(O[C@@H](C3=CC=C(C(O)=O)C=C3)C[C@H]2NC(C4(C5=CC(OC(F)(F)O6)=C6C=C5)CC4)=O)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 559.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Voight EA, Greszler SN, Kym PR. Fueling the Pipeline via Innovations in Organic Synthesis. ACS Med Chem Lett. 2021 Aug 27;12(9):1365-1373. doi: 10.1021/acsmedchemlett.1c00351. PMID: 34531945; PMCID: PMC8436243. 2: Lester A, Sandman M, Herring C, Girard C, Dixon B, Ramsdell H, Reber C, Poulos J, Mitchell A, Spinney A, Henager ME, Evans CN, Turlington M, Johnson QR. Computational Exploration of Potential CFTR Binding Sites for Type I Corrector Drugs. Biochemistry. 2023 Aug 15;62(16):2503-2515. doi: 10.1021/acs.biochem.3c00165. Epub 2023 Jul 12. PMID: 37437308; PMCID: PMC10433520.