Rabdosin B | CAS#84304-92-7 | antitumor

MedKoo Cat#: 461116 | Name: Rabdosin B

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rabdosin B is an ent-kaurene diterpenoid purified from the air-dried aerial parts of Isodon japonica.

Chemical Structure

Rabdosin B

CAS#84304-92-7

Theoretical Analysis

MedKoo Cat#: 461116

Name: Rabdosin B

CAS#: 84304-92-7

Chemical Formula: C24H32O8

Exact Mass: 448.2097

Molecular Weight: 448.51

Elemental Analysis: C, 64.27; H, 7.19; O, 28.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

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Synonym

Rabdosin B;

IUPAC/Chemical Name

((1R,2S,4a'S,5'S,6R,7'S,9a'S)-2-acetoxy-5'-hydroxy-5,5-dimethyl-8'-methylene-1',9'-dioxohexahydro-1'H,3'H-spiro[cyclohexane-1,4'-[7,9a]methanocyclohepta[c]pyran]-6-yl)methyl acetate

InChi Key

LUXJXSFHXOVGTA-DUAAMXSASA-N

InChi Code

InChI=1S/C24H32O8/c1-12-15-8-16(27)19-23(9-15,20(12)28)21(29)31-11-24(19)17(10-30-13(2)25)22(4,5)7-6-18(24)32-14(3)26/h15-19,27H,1,6-11H2,2-5H3/t15-,16+,17-,18+,19-,23+,24+/m1/s1

SMILES Code

CC(OC[C@@H]1C(C)(CC[C@@H]([C@]12COC([C@@]34C[C@H](C(C4=O)=C)C[C@@H]([C@@H]23)O)=O)OC(C)=O)C)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 448.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wang T, Wang X. Molecular structure, vibrational and 13C NMR spectra of two ent-kaurenes spirolactone type diterpenoids rabdosinate and rabdosin B: a combined experimental and density functional methods. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Jan 25;135:568-75. doi: 10.1016/j.saa.2014.07.044. Epub 2014 Jul 27. PubMed PMID: 25123947. 2: Ding L, Jing H, Qin B, Qi L, Li J, Wang T, Liu G. Regulation of cell division and growth in roots of Lactuca sativa L. seedlings by the Ent-Kaurene diterpenoid rabdosin B. J Chem Ecol. 2010 May;36(5):553-63. doi: 10.1007/s10886-010-9783-5. Epub 2010 Apr 8. PubMed PMID: 20376693. 3: Zhang JX, He ZA, Chen ZY, Wang YX, Bai SP, Sun HD. Cytotoxic ent-kaurane diterpenoids from Isodon macrophyllus. J Asian Nat Prod Res. 2009 Aug;11(8):693-7. doi: 10.1080/10286020802361271. PubMed PMID: 20183309. 4: Li JC, Liu CJ, An XZ, Wang MT, Zhao TZ, Yu SZ, Zhao GS, Chen RF. [Studies on the antitumor constituent of Rabdosia japonica (Burm. f) Hara. The structures of rabdosin A and B]. Yao Xue Xue Bao. 1982 Sep;17(9):682-7. Chinese. PubMed PMID: 7158353.