L 366948 | CAS#127819-97-0 | oxytocin receptor antagonist

MedKoo Cat#: 596534 | Name: L 366948

Description:

WARNING: This product is for research use only, not for human or veterinary use.

L 366948 is an oxytocin receptor antagonist.

Chemical Structure

L 366948

CAS#127819-97-0

Theoretical Analysis

MedKoo Cat#: 596534

Name: L 366948

CAS#: 127819-97-0

Chemical Formula: C42H54N8O6

Exact Mass: 766.4166

Molecular Weight: 766.94

Elemental Analysis: C, 65.78; H, 7.10; N, 14.61; O, 12.52

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

L 366948; L-366948; L366948; L 366,948; L-366,948; L366,948;

IUPAC/Chemical Name

24-((1H-imidazol-5-yl)methyl)-13-(sec-butyl)-16-(naphthalen-2-ylmethyl)octadecahydro-2H,12H-dipyrido[1,2-a:1',2'-d]pyrrolo[1,2-j][1,4,7,10,13,16]hexaazacyclooctadecine-6,12,15,18,23,26(6aH)-hexaone

InChi Key

ILLSOIRJMQNTIA-UHFFFAOYSA-N

InChi Code

1S/C42H54N8O6/c1-3-26(2)36-42(56)50-19-9-7-14-35(50)41(55)49-18-8-6-13-33(49)39(53)46-32(23-30-24-43-25-44-30)40(54)48-20-10-15-34(48)38(52)45-31(37(51)47-36)22-27-16-17-28-11-4-5-12-29(28)21-27/h4-5,11-12,16-17,21,24-26,31-36H,3,6-10,13-15,18-20,22-23H2,1-2H3,(H,43,44)(H,45,52)(H,46,53)(H,47,51)

SMILES Code

CCC(C1C(N2CCCCC2C(N3CCCCC3C(NC(Cc4[nH]cnc4)C(N5CCCC5C(NC(Cc(cc6)cc7c6cccc7)C(N1)=O)=O)=O)=O)=O)=O)C

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 766.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Politowska E, Drabik P, Kazmierkiewicz R, Ciarkowsk J. Docking ligands to vasopressin and oxytocin receptors via genetic algorithm. J Recept Signal Transduct Res. 2002 Feb-Nov;22(1-4):393-409. PubMed PMID: 12503629. 2: Hu J, Ludwig TE, Salli U, Stormshak F, Mirando MA. Autocrine/paracrine action of oxytocin in pig endometrium. Biol Reprod. 2001 Jun;64(6):1682-8. PubMed PMID: 11369595. 3: Politowska E, Czaplewski C, Ciarkowski J. Molecular modeling of the oxytocin receptor/bioligand interactions. Acta Biochim Pol. 1999;46(3):581-90. PubMed PMID: 10698266. 4: Yibchok-Anun S, Cheng H, Heine PA, Hsu WH. Characterization of receptors mediating AVP- and OT-induced glucagon release from the rat pancreas. Am J Physiol. 1999 Jul;277(1 Pt 1):E56-62. PubMed PMID: 10409128. 5: Yibchok-anun S, Hsu WH. Effects of arginine vasopressin and oxytocin on glucagon release from clonal alpha-cell line In-R1-G9: involvement of V1b receptors. Life Sci. 1998;63(21):1871-8. PubMed PMID: 9825765. 6: Fejgin MD, Pak SC, Flouret G, Parsons MT, Wilson L Jr. Comparison of the in vivo activity of different oxytocin antagonists in the pregnant baboon. J Soc Gynecol Investig. 1998 Sep-Oct;5(5):251-4. PubMed PMID: 9773400. 7: McMahon LR, Wellman PJ. Assessment of the role of oxytocin receptors in phenylpropanolamine-induced anorexia in rats. Pharmacol Biochem Behav. 1997 Aug;57(4):767-70. PubMed PMID: 9259004. 8: Yu H, Hsu WH. SK&F 105494, a V2-vasopressin receptor antagonist, blocks oxytocin receptors in porcine myometrium. Zhongguo Yao Li Xue Bao. 1996 Jul;17(4):365-8. PubMed PMID: 9812726. 9: Yu H, Zhuge R, Hsu WH. Lysine vasopressin-induced increases in porcine myometrial contractility and intracellular Ca2+ concentrations of myometrial cells: involvement of oxytocin receptors. Biol Reprod. 1995 Mar;52(3):584-590. PubMed PMID: 7756452. 10: Pak SC, Bertoncini D, Meyer W, Scaunas D, Flouret G, Wilson L Jr. Comparison of binding affinity of oxytocin antagonists to human and rat uterine oxytocin receptors and their correlation to the rat uterine oxytocic bioassay. Biol Reprod. 1994 Dec;51(6):1140-4. PubMed PMID: 7888492. 11: Clineschmidt BV, Pettibone DJ, Reiss DR, Lis EV, Haluska GJ, Novy MJ, Cook MJ, Cukierski MA, Kaufman MJ, Bock MG, et al. Antagonism of oxytocin in rats and pregnant rhesus monkeys by the novel cyclic hexapeptides, L-366,682 and L-366,948. J Pharmacol Exp Ther. 1991 Mar;256(3):827-32. PubMed PMID: 2005582. 12: Pettibone DJ, Clineschmidt BV, Lis EV, Reiss DR, Totaro JA, Woyden CJ, Bock MG, Freidinger RM, Tung RD, Veber DF, et al. In vitro pharmacological profile of a novel structural class of oxytocin antagonists. J Pharmacol Exp Ther. 1991 Jan;256(1):304-8. PubMed PMID: 1988661.