E2072 | CAS# 378242-00-3 | GCP-II Inhibitor

MedKoo Cat#: 564980 | Name: E2072

Description:

WARNING: This product is for research use only, not for human or veterinary use.

E2072 is a potent and selective thiol-based Glutamate Carboxypeptidase II (GCP-II) inhibitor.

Chemical Structure

E2072

CAS#378242-00-3

Theoretical Analysis

MedKoo Cat#: 564980

Name: E2072

CAS#: 378242-00-3

Chemical Formula: C16H14O4S

Exact Mass: 302.0613

Molecular Weight: 302.34

Elemental Analysis: C, 63.56; H, 4.67; O, 21.17; S, 10.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

E2072; E-2072; E 2072

IUPAC/Chemical Name

3-(2-Mercaptoethyl)biphenyl-2,3'-dicarboxylic acid

InChi Key

FIILSNMCZCETMG-UHFFFAOYSA-N

InChi Code

InChI=1S/C16H14O4S/c17-15(18)12-5-1-4-11(9-12)13-6-2-3-10(7-8-21)14(13)16(19)20/h1-6,9,21H,7-8H2,(H,17,18)(H,19,20)

SMILES Code

O=C(C1=C(CCS)C=CC=C1C2=CC=CC(C(O)=O)=C2)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 302.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wozniak KM, Wu Y, Vornov JJ, Lapidus R, Rais R, Rojas C, Tsukamoto T, Slusher BS. The orally active glutamate carboxypeptidase II inhibitor E2072 exhibits sustained nerve exposure and attenuates peripheral neuropathy. J Pharmacol Exp Ther. 2012 Dec;343(3):746-54. doi: 10.1124/jpet.112.197665. Epub 2012 Sep 17. PubMed PMID: 22988061. 2: Rais R, Hoover R, Wozniak K, Rudek MA, Tsukamoto T, Alt J, Rojas C, Slusher BS. Reversible disulfide formation of the glutamate carboxypeptidase II inhibitor E2072 results in prolonged systemic exposures in vivo. Drug Metab Dispos. 2012 Dec;40(12):2315-23. doi: 10.1124/dmd.112.046821. Epub 2012 Sep 4. PubMed PMID: 22949627; PubMed Central PMCID: PMC3500546.