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MedKoo Cat#: 127567 | Name: Prinomide trolamine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Prinomide is a carbamoylpyrrolepropionitrile derivative patented by Ciba-Geigy A.-G. as a nonsteroidal anti-inflammatory drug that has disease-modifying activity in rheumatoid arthritis. In clinical trials, Prinomide demonstrate significant improvement in symptom score and laboratory variables.

Chemical Structure

Prinomide trolamine
CAS#77639-70-4 (trolamine)

Theoretical Analysis

MedKoo Cat#: 127567

Name: Prinomide trolamine

CAS#: 77639-70-4 (trolamine)

Chemical Formula: C21H28N4O5

Exact Mass: 416.2060

Molecular Weight: 416.48

Elemental Analysis: C, 60.56; H, 6.78; N, 13.45; O, 19.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
109636-76-2 (tromethamine) 77639-66-8 (free base) 77639-70-4 (trolamine)
Synonym
PRINOMIDE TROLAMINE; CGS-10787B; CGS10787B; CGS 10787B
IUPAC/Chemical Name
2-cyano-3-(1-methyl-1H-pyrrol-2-yl)-3-oxo-N-phenylpropanamide--2,2',2''-nitrilotris(ethan-1-ol) (1/1)
InChi Key
HZXCDXNTMAAZIL-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H13N3O2.C6H15NO3/c1-18-9-5-8-13(18)14(19)12(10-16)15(20)17-11-6-3-2-4-7-11;8-4-1-7(2-5-9)3-6-10/h2-9,12H,1H3,(H,17,20);8-10H,1-6H2
SMILES Code
OCCN(CCO)CCO.CN1C=CC=C1C(=O)C(C#N)C(=O)NC2=CC=CC=C2
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 416.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Egger H, Itterly W, John V, Rodebaugh R, Shimanskas C, Stancato F, Kapoor A. Disposition and metabolism of prinomide in laboratory animals. Drug Metab Dispos. 1988 Jul-Aug;16(4):568-75. PMID: 2903025. 2: Kochak GM, Pai S, Iannucci R, Honc F, Kachmar D, Perrino P, Egger H. Prinomide tromethamine pharmacokinetics: mutually dependent saturable and competitive protein binding between prinomide and its own metabolite. Pharm Res. 1993 Jan;10(1):49-55. doi: 10.1023/a:1018916811904. PMID: 8430060. 3: Cohick CB, Furst DE, Quagliata S, Corcoran KA, Steere KJ, Yager JG, Lindsley HB. Analysis of elevated serum interleukin-6 levels in rheumatoid arthritis: correlation with erythrocyte sedimentation rate or C-reactive protein. J Lab Clin Med. 1994 May;123(5):721-7. PMID: 8195678. 4: Parrish DD, Schlosser MJ, Kapeghian JC, Traina VM. Activation of CGS 12094 (prinomide metabolite) to 1,4-benzoquinone by myeloperoxidase: implications for human idiosyncratic agranulocytosis. Fundam Appl Toxicol. 1997 Feb;35(2):197-204. doi: 10.1006/faat.1996.2270. PMID: 9038241. 5: Bird HA, Hill J, Dixon JS, Bojar R, Traficante A, Catalano MA, Adair SF, Liauw L, Sussman H, Rotman H, et al. A clinical and biochemical assessment of prinomide in patients with rheumatoid arthritis. J Rheumatol. 1989 Apr;16(4):448-54. PMID: 2664168. 6: Doughty JR, Goldberg RL, Schenkelaars EJ, Singh HN, Peppard J, Haston W, Blancuzzi VJ, Di Pasquale G. Relationship of blood markers to disease severity and drug efficacy in rat adjuvant arthritis. Agents Actions. 1991 Sep;34(1-2):129-31. doi: 10.1007/BF01993257. PMID: 1793016. 7: Schenkelaars EJ, Singh HN, Goldberg RL, Doughty JR, Peppard J, DiPasquale G, Quagliata F. Pharmacological modulation of rat monocytes: in vivo effects on Ia expression and interleukin-1 production. Agents Actions. 1991 Sep;34(1-2):66-9. doi: 10.1007/BF01993240. PMID: 1793054. 8: Akita S, Abe C, Hirose S. Effect of a new antirheumatic drug (CGS10787B) on antibody formation and delayed-type hypersensitivity in BALB/c mice. Int J Tissue React. 1988;10(4):199-205. PMID: 3266939. 9: Luders RC, Brunner LA. Automated sample preparation and chromatographic analysis: determination of CGS 10787B and related compounds. J Chromatogr Sci. 1987 May;25(5):192-7. doi: 10.1093/chromsci/25.5.192. PMID: 3597649.