MedKoo Cat#: 599175 | Name: Lonchocarpin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lonchocarpin has anti-bacterial, anti-inflammatory, antiproliferative, antioxidant, and antiepileptic activities; isolated from Abrus precatorius.

Chemical Structure

Lonchocarpin
Lonchocarpin
CAS#31501-55-0

Theoretical Analysis

MedKoo Cat#: 599175

Name: Lonchocarpin

CAS#: 31501-55-0

Chemical Formula: C20H18O3

Exact Mass: 306.1256

Molecular Weight: 306.36

Elemental Analysis: C, 78.41; H, 5.92; O, 15.67

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Lonchocarpin;
IUPAC/Chemical Name
(E)-1-(5-hydroxy-2,2-dimethyl-2H-chromen-6-yl)-3-phenylprop-2-en-1-one
InChi Key
UEXPKLJRGIWQBF-CSKARUKUSA-N
InChi Code
InChI=1S/C20H18O3/c1-20(2)13-12-16-18(23-20)11-9-15(19(16)22)17(21)10-8-14-6-4-3-5-7-14/h3-13,22H,1-2H3/b10-8+
SMILES Code
O=C(C1=CC=C2C(C=CC(C)(C)O2)=C1O)/C=C/C3=CC=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 306.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Cunha GM, Fontenele JB, Nobre Júnior HV, De Sousa FC, Silveira ER, Nogueira NA, De Moraes MO, Viana GS, Costa-Lotufo LV. Cytotoxic activity of chalcones isolated from lonchocarpus sericeus (pocr.) kunth. Phytother Res. 2003 Feb;17(2):155-9. PubMed PMID: 12601679. 2: Fontenele JB, Leal LK, Felix FH, Silveira ER, Viana GS. Studies on the anti-oedematogenic properties of a fraction rich in lonchocarpin and derricin isolated from Lonchocarpus sericeus. Nat Prod Res. 2009;23(18):1677-88. doi: 10.1080/14786410802181745. PubMed PMID: 19921586. 3: Chen G, Zhou D, Li XZ, Jiang Z, Tan C, Wei XY, Ling J, Jing J, Liu F, Li N. A natural chalcone induces apoptosis in lung cancer cells: 3D-QSAR, docking and an in vivo/vitro assay. Sci Rep. 2017 Sep 6;7(1):10729. doi: 10.1038/s41598-017-11369-9. PubMed PMID: 28878321; PubMed Central PMCID: PMC5587747. 4: Li J, Jiang Z, Li X, Hou Y, Liu F, Li N, Liu X, Yang L. Natural therapeutic agents for neurodegenerative diseases from a traditional herbal medicine Pongamia pinnata (L.) Pierre. Bioorg Med Chem Lett. 2015 Jan 1;25(1):53-8. Epub 2014 Nov 11. PubMed PMID: 25466192. 5: Gonçalves de Lima O, de Méllo JF, de Barros Coêlho JS, de Andrade Lyra FD, Machado de Albuquerque M, Marini-Bettólo GB, Delle Monache G, Delle Monache F. New prenylated chalcones from Lonchocarpus neuroscapha Benth. (Cordoa piaca). Farmaco Sci. 1975 May;30(5):326-42. PubMed PMID: 1175760. 6: Reyes-Chilpa R, Baggio CH, Alavez-Solano D, Estrada-Muñiz E, Kauffman FC, Sanchez RI, Mesia-Vela S. Inhibition of gastric H+,K+-ATPase activity by flavonoids, coumarins and xanthones isolated from Mexican medicinal plants. J Ethnopharmacol. 2006 Apr 21;105(1-2):167-72. Epub 2005 Nov 28. PubMed PMID: 16314059. 7: De Méllo JF, De Lima OG, De Albuquerque MM, Marini-Bettòlo GB, Lyra FD, Da Silva EC. [O and C prenylated chalcones with antineoplastic and antibiotic activities isolated from Lonchocarpus neuroscapha Benth]. Rev Inst Antibiot (Recife). 1974 Dec;14(1-2):39-50. Portuguese. PubMed PMID: 4471335.