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MedKoo Cat#: 575541 | Name: Flunisolide acetate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Flunisolide acetate is a corticosteroid used as a treatment for allergic rhinitis.

Chemical Structure

Flunisolide acetate
Flunisolide acetate
CAS#4533-89-5 (acetate)

Theoretical Analysis

MedKoo Cat#: 575541

Name: Flunisolide acetate

CAS#: 4533-89-5 (acetate)

Chemical Formula: C26H33FO7

Exact Mass: 476.2210

Molecular Weight: 476.54

Elemental Analysis: C, 65.53; H, 6.98; F, 3.99; O, 23.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
3385-03-3 4533-89-5 (acetate) 77326-96-6 (hemihydrate)
Synonym
Flunisolide acetate; RS-1320; RS1320; RS 1320
IUPAC/Chemical Name
2-((2S,6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-2-fluoro-7-hydroxy-6a,8a,10,10-tetramethyl-4-oxo-1,2,4,6a,6b,7,8,8a,11a,12,12a,12b-dodecahydro-8bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoethyl acetate
InChi Key
WEGNFRKBIKYVLC-XTLNBZDDSA-N
InChi Code
InChI=1S/C26H33FO7/c1-13(28)32-12-20(31)26-21(33-23(2,3)34-26)10-16-15-9-18(27)17-8-14(29)6-7-24(17,4)22(15)19(30)11-25(16,26)5/h6-8,15-16,18-19,21-22,30H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,22+,24-,25-,26+/m0/s1
SMILES Code
C(COC(C)=O)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(OC(C)(C)O2)[H])([C@]4([C@]([C@@H](O)C3)([C@]5(C)C([C@@H](F)C4)=CC(=O)C=C5)[H])[H])[H]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 476.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Berger WE, Tashkin DP. Flunisolide hydrofluoroalkane with integrated spacer for treating asthma: an updated review. Allergy Asthma Proc. 2015 Mar-Apr;36(2):105-15. doi: 10.2500/aap.2015.36.3835. Epub 2015 Jan 29. Review. PubMed PMID: 25635610. 2: Melani AS. Flunisolide for the treatment of asthma. Expert Rev Clin Pharmacol. 2014 May;7(3):251-8. doi: 10.1586/17512433.2014.908117. Epub 2014 Apr 9. Review. PubMed PMID: 24716719. 3: Kantar A, Mroueh S, Fiocchi A. A reappraisal of the clinical efficacy of nebulized flunisolide in pediatric asthma: the Italian experience. Allergy Asthma Proc. 2007 Nov-Dec;28(6):671-87. Review. PubMed PMID: 17883883. 4: Corren J, Tashkin DP. Evaluation of efficacy and safety of flunisolide hydrofluoroalkane for the treatment of asthma. Clin Ther. 2003 Mar;25(3):776-98. Review. PubMed PMID: 12852702. 5: Kakhnovskiĭ IM, Solomatin AS. [Beclomethasone dipropionate, budesonide and flunisolide in the treatment of bronchial asthma (a review of the literature and the authors' own research)]. Ter Arkh. 1995;67(3):34-8. Review. Russian. PubMed PMID: 7770801.