Synonym
Iodoxamate Meglumine; Endobil; EINECS 257-398-6
IUPAC/Chemical Name
Benzoic acid, 3,3'-((1,16-dioxo-4,7,10,13-tetraoxahexadecane-1,16-diyl)diimino)bis(2,4,6-triiodo-, compound with 1-deoxy-1-(methylamino)-D-glucitol (1:2)
InChi Key
LNBGFESBSAEKAE-VRWDCWMNSA-N
InChi Code
InChI=1S/C26H26I6N2O10.2C7H17NO5/c27-13-11-15(29)23(21(31)19(13)25(37)38)33-17(35)1-3-41-5-7-43-9-10-44-8-6-42-4-2-18(36)34-24-16(30)12-14(28)20(22(24)32)26(39)40;2*1-8-2-4(10)6(12)7(13)5(11)3-9/h11-12H,1-10H2,(H,33,35)(H,34,36)(H,37,38)(H,39,40);2*4-13H,2-3H2,1H3/t;2*4-,5+,6+,7+/m.00/s1
SMILES Code
O=C(NC1=C(I)C(C(O)=O)=C(I)C=C1I)CCOCCOCCOCCOCCC(NC2=C(I)C(C(O)=O)=C(I)C=C2I)=O.O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC.O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)CNC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
1,678.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Taenzer V, Volkhardt V. Double blind comparison of meglumine iotroxate (Biliscopin), meglumine iodoxamate (Endobil), and meglumine ioglycamate (Biligram). AJR Am J Roentgenol. 1979 Jan;132(1):55-8. doi: 10.2214/ajr.132.1.55. PMID: 103404.
2: Wallers KJ, McDermott P, James WB. Intravenous cholangiography by bolus injection of meglumine iotroxamate and meglumine iodoxamate: a comparative trial of two new contrast media. Clin Radiol. 1981 Jul;32(4):457-9. doi: 10.1016/s0009-9260(81)80304-2. PMID: 6894722.
3: Swanson DP, Dick TJ, Simms SM, Thrall JH. Product selection criteria for intravascular ionic contrast media. Clin Pharm. 1985 Sep-Oct;4(5):527-38. PMID: 3902331.
4: Dohmen JP, Lemmens JA, Lamers JJ. A double-blind comparison of meglumine iotroxate (Biliscopin) and meglumine iodoxamate (Cholovue). Diagn Imaging. 1981;50(6):305-8. PMID: 7035108.
5: Robbins AH, Sargent EN, Vincent ME, Boswell W, Meyers HI. Double-blind comparison of meglumine lodoxamate (Cholovue) and meglumine iodipamide (Cholografin). AJR Am J Roentgenol. 1976 Aug;127(2):257-60. doi: 10.2214/ajr.127.2.257. PMID: 182003.
6: Robbins AH, Earampamoorthy S, Koff RS, Di Fazio LT, Wickis EA, Gertler AN. Successful intravenous cholecystocholangiography in the jaundiced patient using meglumine iodoxamate (Cholovue). AJR Am J Roentgenol. 1976 Jan;126(1):70-6. doi: 10.2214/ajr.126.1.70. PMID: 175687.
7: Nilsson U. Adverse reactions to iotroxate at intravenous cholangiography. A prospective clinical investigation and review of the literature. Acta Radiol. 1987 Sep-Oct;28(5):571-5. PMID: 2960350.
8: Zaunbauer W, Grandjean EM, Paumgartner G, Fuchs WA. Die Kinetik der biliären Ausscheidung der Gallekontrastmittel Ioglycamid, Iodoxamat und Iotroxamat beim Hund [Biliary excretion kinetics of the biliary contrast media ioglycamide, iodoxamate and iotroxamate in the dog]. Schweiz Med Wochenschr. 1981 Jan 31;111(5):157-61. German. PMID: 6895123.
9: Fumino S, Ono S, Kimura O, Deguchi E, Iwai N. Diagnostic impact of computed tomography cholangiography and magnetic resonance cholangiopancreatography on pancreaticobiliary maljunction. J Pediatr Surg. 2011 Jul;46(7):1373-8. doi: 10.1016/j.jpedsurg.2011.01.026. PMID: 21763837.
10: Fleischmann D, Ringl H, Schöfl R, Pötzi R, Kontrus M, Henk C, Bankier AA, Kettenbach J, Mostbeck GH. Three-dimensional spiral CT cholangiography in patients with suspected obstructive biliary disease: comparison with endoscopic retrograde cholangiography. Radiology. 1996 Mar;198(3):861-8. doi: 10.1148/radiology.198.3.8628884. PMID: 8628884.
