Synonym
Desbromoleptophos; Debromoleptophos;
IUPAC/Chemical Name
O-(2,5-Dichlorophenyl) O-methyl phenyl thiophosphonate
InChi Key
BCMQSEIBTPUGQQ-UHFFFAOYSA-N
InChi Code
InChI=1S/C13H12Cl2O2PS/c1-17(13-9-10(14)7-8-12(13)15)18(19)16-11-5-3-2-4-6-11/h2-9,18H,1H3
SMILES Code
S=P(O(C1=CC(Cl)=CC=C1Cl)C)OC2=CC=CC=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
334.17
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Farage-Elawar M, Duffy JS, Francis BM. Developmental toxicity of desbromoleptophos in chicks: enzyme inhibition, malformations and functional deficits. Neurotoxicol Teratol. 1991 Jan-Feb;13(1):91-7. PubMed PMID: 1710763.
2: Farage-Elawar M, Francis BM. Effects of fenthion, fenitrothion and desbromoleptophos on gait, acetylcholinesterase, and neurotoxic esterase in young chicks after in ovo exposure. Toxicology. 1988 May;49(2-3):253-61. PubMed PMID: 2453943.
3: Farage-Elawar M, Francis BM. Effects of multiple dosing of fenthion, fenitrothion, and desbromoleptophos in young chicks. J Toxicol Environ Health. 1988;23(2):217-28. PubMed PMID: 2449534.
4: Francis BM. Effects of structure, atropine, and dosing regimen on the delayed neurotoxicity of the insecticide EPN. Bull Environ Contam Toxicol. 1987 Feb;38(2):283-8. PubMed PMID: 2432974.
5: Farage-Elawar M, Francis BM. Acute and delayed effects of fenthion in young chicks. J Toxicol Environ Health. 1987;21(4):455-69. PubMed PMID: 2439699.
6: Francis BM, Hansen LG, Fukuto TR, Lu PY, Metcalf RL. Ecotoxicology of phenylphosphonothioates. Environ Health Perspect. 1980 Jun;36:187-95. PubMed PMID: 6159210; PubMed Central PMCID: PMC1637739.
7: Allahyari R, Hollingshaus JG, Lapp RL, Timm E, Jacobson RA, Fukuto TR. Resolution, absolute configuration, and acute and delayed neurotoxicity of the chiral isomers of O-aryl O-methyl phenylphosphonothioate analogues related to leptophos. J Agric Food Chem. 1980 May-Jun;28(3):594-9. PubMed PMID: 6156190.
8: Abou-Donia MB. Delayed neurotoxicity of phenylphosphonothioate esters. Science. 1979 Aug 17;205(4407):713-5. PubMed PMID: 462181.
