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MedKoo Cat#: 202963 | Name: Totrombopag

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Totrombopag, also known as SB559448, LGD-4665; is being developed by GlaxoSmithKline, which a back-up compound for eltrombopag (SB-497115).

Chemical Structure

Totrombopag
Totrombopag
CAS#376592-42-6 (free base)

Theoretical Analysis

MedKoo Cat#: 202963

Name: Totrombopag

CAS#: 376592-42-6 (free base)

Chemical Formula: C25H22N8O2

Exact Mass: 466.1866

Molecular Weight: 466.49

Elemental Analysis: C, 64.37; H, 4.75; N, 24.02; O, 6.86

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
376592-42-6 (free base) 851606-62-7 (choline)
Synonym
SB559448; SB 559448; SB-559448; LGD-4665; LGD4665; LGD 4665; GSK2285921; GSK-2285921; GSK 2285921; C116875; Totrombopag.
IUPAC/Chemical Name
(E)-1-(3,4-dimethylphenyl)-4-((2-hydroxy-3'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-3-yl)diazenyl)-3-methyl-1H-pyrazol-5(4H)-one.
InChi Key
KWJKFQSAMABKBG-CYYJNZCTSA-N
InChi Code
InChI=1S/C25H22N8O2/c1-14-10-11-19(12-15(14)2)33-25(35)22(16(3)30-33)27-26-21-9-5-8-20(23(21)34)17-6-4-7-18(13-17)24-28-31-32-29-24/h4-13,22,34H,1-3H3,(H,28,29,31,32)/b27-26+
SMILES Code
O=C1C(/N=N/C2=C(O)C(C3=CC=CC(C4=NNN=N4)=C3)=CC=C2)C(C)=NN1C5=CC=C(C)C(C)=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>5 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
 Related CAS# 376592-42-6 (Totrombopag) 851606-62-7 (Totrombopag choline)  

Preparing Stock Solutions

The following data is based on the product molecular weight 466.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor. Alper, Phil B.; Marsilje, Thomas H.; Mutnick, Daniel; Lu, Wenshuo; Chatterjee, Arnab; Roberts, Michael J.; He, Yun; Karanewsky, Donald S.; Chow, Donald; Lao, Jianmin; Gerken, Andrea; Tuntland, Tove; Liu, Bo; Chang, Jonathan; Gordon, Perry; Seidel, H. Martin; Tian, Shin-Shay. Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA, USA. Bioorganic & Medicinal Chemistry Letters (2008), 18(19), 5255-5258. Publisher: Elsevier Ltd., CODEN: BMCLE8 ISSN: 0960-894X. Journal written in English. CAN 149:548251 AN 2008:1138522 CAPLUS