Neomyosuppressin | CAS#143458-86-0 | myoinhibiting neuropeptide

MedKoo Cat#: 598669 | Name: Neomyosuppressin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Neomyosuppressin is a myoinhibiting neuropeptide from the grey fleshfly, Neobellieria bullata & Drosophila.

Chemical Structure

Neomyosuppressin

CAS#143458-86-0

Theoretical Analysis

MedKoo Cat#: 598669

Name: Neomyosuppressin

CAS#: 143458-86-0

Chemical Formula: C58H86N16O15

Exact Mass: 1246.6459

Molecular Weight: 1247.42

Elemental Analysis: C, 55.85; H, 6.95; N, 17.97; O, 19.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Neomyosuppressin; Neb-MS; Dromyosuppressin; Thr-asp-val-asp-his-val-phe-leu-arg-phenh2;

IUPAC/Chemical Name

(6S,9S,12S,15S,18S,21S,24S,27S)-18-((1H-imidazol-4-yl)methyl)-1-amino-6-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-27-((2S,3R)-2-amino-3-hydroxybutanamido)-12-benzyl-21-(carboxymethyl)-1-imino-9-isobutyl-15,24-diisopropyl-8,11,14,17,20,23,26-heptaoxo-2,7,10,13,16,19,22,25-octaazanonacosan-29-oic acid

InChi Key

XYBRAEZMEMTADX-XESIXFTMSA-N

InChi Code

InChI=1S/C58H86N16O15/c1-29(2)21-38(50(82)66-36(19-14-20-64-58(61)62)49(81)67-37(48(60)80)22-33-15-10-8-11-16-33)68-51(83)39(23-34-17-12-9-13-18-34)71-56(88)46(30(3)4)73-53(85)40(24-35-27-63-28-65-35)69-52(84)41(25-43(76)77)72-57(89)47(31(5)6)74-54(86)42(26-44(78)79)70-55(87)45(59)32(7)75/h8-13,15-18,27-32,36-42,45-47,75H,14,19-26,59H2,1-7H3,(H2,60,80)(H,63,65)(H,66,82)(H,67,81)(H,68,83)(H,69,84)(H,70,87)(H,71,88)(H,72,89)(H,73,85)(H,74,86)(H,76,77)(H,78,79)(H4,61,62,64)/t32-,36+,37+,38+,39+,40+,41+,42+,45+,46+,47+/m1/s1

SMILES Code

O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](C(C)C)NC([C@H](CC3=CNC=N3)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)N)=O)=O)=O)=O)=O)=O)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,247.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fónagy A, Schoofs L, Proost P, Van Damme J, Bueds H, De Loof A. Isolation, primary structure and synthesis of neomyosuppressin, a myoinhibiting neuropeptide from the grey fleshfly, Neobellieria bullata. Comp Biochem Physiol C. 1992 Jun;102(2):239-45. PubMed PMID: 1358537. 2: McCormick J, Nichols R. Spatial and temporal expression identify dromyosuppressin as a brain-gut peptide in Drosophila melanogaster. J Comp Neurol. 1993 Dec 8;338(2):278-88. PubMed PMID: 8308172. 3: Heifetz Y, Lindner M, Garini Y, Wolfner MF. Mating regulates neuromodulator ensembles at nerve termini innervating the Drosophila reproductive tract. Curr Biol. 2014 Mar 31;24(7):731-7. doi: 10.1016/j.cub.2014.02.042. Epub 2014 Mar 13. PubMed PMID: 24631240; PubMed Central PMCID: PMC4020355. 4: Bass C, Katanski C, Maynard B, Zurro I, Mariane E, Matta M, Loi M, Melis V, Capponi V, Muroni P, Setzu M, Nichols R. Conserved residues in RF-NH₂ receptor models identify predicted contact sites in ligand-receptor binding. Peptides. 2014 Mar;53:278-85. doi: 10.1016/j.peptides.2013.06.009. Epub 2013 Jun 26. PubMed PMID: 23811075. 5: Kiss B, Szlanka T, Zvara Á, Žurovec M, Sery M, Kakaš Š, Ramasz B, Hegedűs Z, Lukacsovich T, Puskás L, Fónagy A, Kiss I. Selective elimination/RNAi silencing of FMRF-related peptides and their receptors decreases the locomotor activity in Drosophila melanogaster. Gen Comp Endocrinol. 2013 Sep 15;191:137-45. doi: 10.1016/j.ygcen.2013.05.023. Epub 2013 Jun 11. PubMed PMID: 23770020. 6: Nichols R, McCormick J, Lim I. Dromyosuppressin and drosulfakinin, two structurally related Drosophila neuropeptides, are uniquely expressed in the adult central nervous system. Ann N Y Acad Sci. 1997 Apr 24;814:315-8. PubMed PMID: 9160985. 7: Klose MK, Dason JS, Atwood HL, Boulianne GL, Mercier AJ. Peptide-induced modulation of synaptic transmission and escape response in Drosophila requires two G-protein-coupled receptors. J Neurosci. 2010 Nov 3;30(44):14724-34. doi: 10.1523/JNEUROSCI.3612-10.2010. PubMed PMID: 21048131. 8: Nichols R. Signaling pathways and physiological functions of Drosophila melanogaster FMRFamide-related peptides. Annu Rev Entomol. 2003;48:485-503. Epub 2002 Jun 4. Review. PubMed PMID: 12414735. 9: Kaminski S, Orlowski E, Berry K, Nichols R. The effects of three Drosophila melanogaster myotropins on the frequency of foregut contractions differ. J Neurogenet. 2002 Apr-Jun;16(2):125-34. PubMed PMID: 12479379. 10: Meola SM, Wright MS, Nichols R, Pendleton MW. Localization of myosuppressinlike peptides in the hypocerebral ganglion of two blood-feeding flies: horn fly and stable fly (Diptera:Muscidae). J Med Entomol. 1996 May;33(3):473-81. PubMed PMID: 8667397. 11: Nichols R, Bendena WG, Tobe SS. Myotropic peptides in Drosophila melanogaster and the genes that encode them. J Neurogenet. 2002 Jan-Mar;16(1):1-28. Review. PubMed PMID: 12420787. 12: Johnson EC, Bohn LM, Barak LS, Birse RT, Nässel DR, Caron MG, Taghert PH. Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions. J Biol Chem. 2003 Dec 26;278(52):52172-8. Epub 2003 Oct 10. PubMed PMID: 14555656. 13: Angioy AM, Muroni P, Barbarossa IT, McCormick J, Nichols R. Evidence dromyosuppressin acts at posterior and anterior pacemakers to decrease the fast and the slow cardiac activity in the blowfly Protophormia terraenovae. Peptides. 2007 Mar;28(3):585-93. Epub 2006 Dec 4. PubMed PMID: 17141921; PubMed Central PMCID: PMC3422744. 14: Richer S, Stoffolano JG Jr, Yin CM, Nichols R. Innervation of dromyosuppressin (DMS) immunoreactive processes and effect of DMS and benzethonium chloride on the Phormia regina (Meigen) crop. J Comp Neurol. 2000 May 22;421(1):136-42. PubMed PMID: 10813776. 15: Tibbetts MF, Nichols R. Immunocytochemistry of sequence-related neuropeptides in Drosophila. Neuropeptides. 1993 Jun;24(6):321-5. PubMed PMID: 8350979.