Oglemilast, also known as GRC 3886, is a potent and selective PDE4 inhibitor (IC50: 2.5 nM (PDE4B) and 1.7 nM (PDE4D)). Oglemilast was a drug under development to treat chronic obstructive pulmonary disorder (COPD)—a lung disease—and asthma. In 2009, Phase IIb trials was failed.
MedKoo Cat#: 127394
Name: Oglemilast sodium
CAS#: Oglemilast sodium
Chemical Formula: C20H12Cl2F2N3NaO5S
Exact Mass: 536.9740
Molecular Weight: 538.28
Elemental Analysis: C, 44.63; H, 2.25; Cl, 13.17; F, 7.06; N, 7.81; Na, 4.27; O, 14.86; S, 5.96
The following data is based on the product molecular weight 538.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
