Oglemilast, also known as GRC 3886, is a potent and selective PDE4 inhibitor (IC50: 2.5 nM (PDE4B) and 1.7 nM (PDE4D)). Oglemilast was a drug under development to treat chronic obstructive pulmonary disorder (COPD)—a lung disease—and asthma. In 2009, Phase IIb trials was failed.
MedKoo Cat#: 326771
Name: Oglemilast
CAS#: 778576-62-8 (free acid)
Chemical Formula: C20H13Cl2F2N3O5S
Exact Mass: 514.9921
Molecular Weight: 516.30
Elemental Analysis: C, 46.53; H, 2.54; Cl, 13.73; F, 7.36; N, 8.14; O, 15.49; S, 6.21
The following data is based on the product molecular weight 516.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
