Talabostat, also known as PT-100 and BXCL701, is dipeptidyl peptidase inhibitor with antineoplastic and hematopoiesis- stimulating activities. By cleaving N-terminal Xaa-Pro or Xaa-Ala residues, talabostat inhibits dipeptidyl peptidases, such as fibroblast activation protein (FAP), resulting in the stimulation of cytokine and chemokine production and specific T-cell immunity and T-cell- dependent activity. This agent may also stimulate the production of colony stimulating factors, such as granulocyte colony stimulating factor (G-CSF), resulting in the stimulation of hematopoiesis. Dipeptidyl peptidases are involved in the activation of polypeptide hormones and chemokines.
MedKoo Cat#: 202730
Name: Talabostat mesylate
CAS#: 150080-09-4 (mesylate)
Chemical Formula: C10H23BN2O6S
Exact Mass: 214.1500
Molecular Weight: 310.17
Elemental Analysis: C, 50.50; H, 8.95; B, 5.05; N, 13.09; O, 22.42
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 62.0 | 199.88 | |
| Water | 62.0 | 199.88 | |
| Ethanol | 62.0 | 199.88 |
The following data is based on the product molecular weight 310.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
