VRX-480773 | CAS#N/A

MedKoo Cat#: 535110 | Name: VRX-480773

Description:

WARNING: This product is for research use only, not for human or veterinary use.

VRX-480773 is a Novel Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI).

Chemical Structure

VRX-480773

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 535110

Name: VRX-480773

CAS#: N/A

Chemical Formula: C23H19BrClN5O3S2

Exact Mass: 590.9801

Molecular Weight: 592.91

Elemental Analysis: C, 46.59; H, 3.23; Br, 13.48; Cl, 5.98; N, 11.81; O, 8.10; S, 10.81

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

VRX-480773; VRX 480773; VRX480773

IUPAC/Chemical Name

2-[[5-Bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-chloro-4-sulfamoylphenyl)acetamide

InChi Key

JMAGRGYNUBAGRG-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H19BrClN5O3S2/c24-22-28-29-23(34-12-21(31)27-19-9-7-14(11-18(19)25)35(26,32)33)30(22)20-10-8-15(13-5-6-13)16-3-1-2-4-17(16)20/h1-4,7-11,13H,5-6,12H2,(H,27,31)(H2,26,32,33)

SMILES Code

O=C(NC1=CC=C(S(=O)(N)=O)C=C1Cl)CSC2=NN=C(Br)N2C3=C4C=CC=CC4=C(C5CC5)C=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 592.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Wan ZY, Tao Y, Wang YF, Mao TQ, Yin H, Chen FE, Piao HR, De Clercq E, Daelemans D, Pannecouque C. Hybrid chemistry. Part 4: Discovery of etravirine- VRX-480773 hybrids as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorg Med Chem. 2015 Aug 1;23(15):4248-4255. doi: 10.1016/j.bmc.2015.06.048. Epub 2015 Jun 27. PMID: 26162497. 2: Zhang Z, Xu W, Koh YH, Shim JH, Girardet JL, Yeh LT, Hamatake RK, Hong Z. A novel nonnucleoside analogue that inhibits human immunodeficiency virus type 1 isolates resistant to current nonnucleoside reverse transcriptase inhibitors. Antimicrob Agents Chemother. 2007 Feb;51(2):429-37. doi: 10.1128/AAC.01032-06. Epub 2006 Nov 20. PMID: 17116677; PMCID: PMC1797749. 3: Li W, Li X, De Clercq E, Zhan P, Liu X. Discovery of potent HIV-1 non- nucleoside reverse transcriptase inhibitors from arylthioacetanilide structural motif. Eur J Med Chem. 2015 Sep 18;102:167-79. doi: 10.1016/j.ejmech.2015.07.043. Epub 2015 Jul 26. PMID: 26276432. 4: Wan ZY, Yao J, Tao Y, Mao TQ, Wang XL, Lu YP, Wang HF, Yin H, Wu Y, Chen FE, De Clercq E, Daelemans D, Pannecouque C. Discovery of piperidin-4-yl- aminopyrimidine derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Eur J Med Chem. 2015 Jun 5;97:1-9. doi: 10.1016/j.ejmech.2015.04.050. Epub 2015 Apr 27. PMID: 25935383. 5: Jochmans D, Anders M, Keuleers I, Smeulders L, Kräusslich HG, Kraus G, Müller B. Selective killing of human immunodeficiency virus infected cells by non- nucleoside reverse transcriptase inhibitor-induced activation of HIV protease. Retrovirology. 2010 Oct 15;7:89. doi: 10.1186/1742-4690-7-89. PMID: 20950436; PMCID: PMC2974656. 6: Wan ZY, Yao J, Mao TQ, Wang XL, Wang HF, Chen WX, Yin H, Chen FE, De Clercq E, Daelemans D, Pannecouque C. Pyrimidine sulfonylacetanilides with improved potency against key mutant viruses of HIV-1 by specific targeting of a highly conserved residue. Eur J Med Chem. 2015 Sep 18;102:215-22. doi: 10.1016/j.ejmech.2015.08.007. Epub 2015 Aug 7. PMID: 26276435.

View History

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