Coelogin | CAS#82358-31-4 | phenanthrene derivative

MedKoo Cat#: 145252 | Name: Coelogin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Coelogin is a phenanthrene derivative isolated from the ethanolic extract of Coelogyne cristata. Coelogin stimulates osteoblastogenesis and its osteoprotective and bone regenerating potential.

Chemical Structure

Coelogin

CAS#82358-31-4

Theoretical Analysis

MedKoo Cat#: 145252

Name: Coelogin

CAS#: 82358-31-4

Chemical Formula: C17H16O5

Exact Mass: 300.0998

Molecular Weight: 300.31

Elemental Analysis: C, 67.99; H, 5.37; O, 26.64

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Coelogin;

IUPAC/Chemical Name

7,8-dimethoxy-9,10-dihydro-5H-naphtho[8,1,2-cde]chromene-2,6-diol

InChi Key

QLYYIQVXUQYKGV-UHFFFAOYSA-N

InChi Code

1S/C17H16O5/c1-20-16-10-4-3-8-5-9(18)6-12-13(8)14(10)11(7-22-12)15(19)17(16)21-2/h5-6,18-19H,3-4,7H2,1-2H3

SMILES Code

COC1=C(OC)C2=C3C(COC4=C3C(CC2)=CC(O)=C4)=C1O

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 300.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Prakash R, Mishra T, Dev K, Sharma K, Kuldeep J, John AA, Tripathi A, Sharma C, Arya KR, Kumar B, Siddiqi MI, Tadigoppula N, Singh D. Phenanthrenoid Coelogin Isolated from Coelogyne cristata Exerts Osteoprotective Effect Through MAPK- Mitogen-Activated Protein Kinase Signaling Pathway. Calcif Tissue Int. 2021 Jul;109(1):32-43. doi: 10.1007/s00223-021-00818-3. Epub 2021 Mar 6. PMID: 33675370. 2: Gupta S, Mishra T, Varshney S, Kushawaha V, Khandelwal N, Rai P, Garg R, Dev K, Gupta A, Kumar D, Balaramnavar VM, Arya KR, Gayen JR, Narender T, Gaikwad AN. Coelogin ameliorates metabolic dyshomeostasis by regulating adipogenesis and enhancing energy expenditure in adipose tissue. Pharmacol Res. 2021 Oct;172:105776. doi: 10.1016/j.phrs.2021.105776. Epub 2021 Aug 25. PMID: 34450319. 3: Sharma C, Mansoori MN, Dixit M, Shukla P, Kumari T, Bhandari SP, Narender T, Singh D, Arya KR. Ethanolic extract of Coelogyne cristata Lindley (Orchidaceae) and its compound coelogin promote osteoprotective activity in ovariectomized estrogen deficient mice. Phytomedicine. 2014 Oct 15;21(12):1702-7. doi: 10.1016/j.phymed.2014.08.008. Epub 2014 Sep 16. PMID: 25442280. 4: Majumder PL, Sen S, Majumder S. Phenanthrene derivatives from the orchid Coelogyne cristata. Phytochemistry. 2001 Oct;58(4):581-6. doi: 10.1016/s0031-9422(01)00287-4. PMID: 11576602.