Synonym
Delmadinone Free Base; Delmadinon; Delmadinona; Delmadinonum
IUPAC/Chemical Name
6-Chloro-17alpha-hydroxy-1,4,6-pregnatrien-3,20-dione
InChi Key
ZSAMZEYLGUEVJW-TTYLFXKOSA-N
InChi Code
InChI=1S/C21H25ClO3/c1-12(23)21(25)9-6-16-14-11-18(22)17-10-13(24)4-7-19(17,2)15(14)5-8-20(16,21)3/h4,7,10-11,14-16,25H,5-6,8-9H2,1-3H3/t14-,15+,16+,19-,20+,21+/m1/s1
SMILES Code
CC([C@@]1(O)CC[C@@]2([H])[C@]3([H])C=C(Cl)C4=CC(C=C[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
| Solubility |
| To be determined |
0.0 |
0.00 |
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
360.88
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Marshall FJ. Use of delmadinone acetate. Vet Rec. 1979 Jun 2;104(22):511-2. doi: 10.1136/vr.104.22.511-a. PMID: 90422.
2: Albouy M, Sanquer A, Maynard L, Eun HM. Efficacies of osaterone and delmadinone in the treatment of benign prostatic hyperplasia in dogs. Vet Rec. 2008 Aug 9;163(6):179-83. doi: 10.1136/vr.163.6.179. PMID: 18689779.
3: Fry PD. Use of delmadinone acetate in pseudopregnancy in the bitch. Vet Rec. 1980 Mar 29;106(13):297. doi: 10.1136/vr.106.13.297-a. PMID: 6156535.
4: Court EA, Watson AD, Church DB, Emslie DR. Effects of delmadinone acetate on pituitary-adrenal function, glucose tolerance and growth hormone in male dogs. Aust Vet J. 1998 Aug;76(8):555-60. doi: 10.1111/j.1751-0813.1998.tb10216.x. PMID: 9741725.
5: Kempker K, Güssow A, Neiger R. Transienter, sekundärer Hypoadrenokortizismus nach Behandlung mit Delmadinonacetat (Tardastrex®) bei einem zwei Jahre alten Rüden [Transient, secondary hypoadrenocorticism after treatment with delmadinone acetate (Tardastrex®) in a two year old male dog]. Schweiz Arch Tierheilkd. 2016 Mar;158(3):193-7. German. doi: 10.17236/sat00056. PMID: 27518315.
6: Tao Y, Paula R, Stolker AA, Chen D, Yuan Z. Simultaneous determination of seven gestagens in kidney fats by Ultra Performance Convergence Chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 15;988:143-8. doi: 10.1016/j.jchromb.2015.02.034. Epub 2015 Mar 2. PMID: 25777477.
7: Romagnoli S. Progestins to control feline reproduction: Historical abuse of high doses and potentially safe use of low doses. J Feline Med Surg. 2015 Sep;17(9):743-52. doi: 10.1177/1098612X15594987. PMID: 26323797.
8: Kent JS. Implant pellets I: effects of compression pressure on in vivo dissolution of delmadinone acetate pellets. J Pharm Sci. 1976 Jan;65(1):89-92. doi: 10.1002/jps.2600650118. PMID: 56437.
9: Lange K, Cordes EK, Hoppen HO, Günzel-Apel AR. Determination of concentrations of sex steroids in blood plasma and semen of male dogs treated with delmadinone acetate or finasteride. J Reprod Fertil Suppl. 2001;57:83-91. PMID: 11787194.
10: Ficus HJ, Jöchle W. Erwünschte und unerwünschte Gestagenwirkungen bei der Hündin. Berücksichtigung bei der Entwicklung eines neuen Gestagens, Delmadinonazetat [Desirable and undesirable gestagen effects in a bitch, with reference to the development of a new gestagen, delmadinone acetate]. Tierarztl Prax. 1975;3(2):231-41. German. PMID: 53910.
