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MedKoo Cat#: 598587 | Name: Lepetine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Lepetine is an alkaloid isolated from the root of Aconitum psedohuiliense.

Chemical Structure

Lepetine
Lepetine
CAS#111509-08-1

Theoretical Analysis

MedKoo Cat#: 598587

Name: Lepetine

CAS#: 111509-08-1

Chemical Formula: C24H35NO4

Exact Mass: 401.2566

Molecular Weight: 401.54

Elemental Analysis: C, 71.79; H, 8.79; N, 3.49; O, 15.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Lepetine;
IUPAC/Chemical Name
(6S,6aR,6bR,7S,8S,10R,11S,11aR,13S)-1-ethyl-6,10-dihydroxy-3-methyl-9-methylenedodecahydro-8H-3,6a,11-(epiethane[1,1,2]triyl)-8,10a-ethanoindeno[2,1-b]azocin-7-yl acetate
InChi Key
WYDGCJLTZZIEHA-PXZNTBKDSA-N
InChi Code
InChI=1S/C24H35NO4/c1-5-25-11-22(4)8-7-17(27)24-16(22)10-15(20(24)25)23-9-6-14(12(2)21(23)28)18(19(23)24)29-13(3)26/h14-21,27-28H,2,5-11H2,1,3-4H3/t14-,15+,16-,17-,18-,19+,20+,21+,22?,23?,24+/m0/s1
SMILES Code
CCN1CC2(C)CC[C@H](O)[C@@]34[C@H]2C[C@@H](C56[C@H]4[C@@H](OC(C)=O)[C@H](C([C@H]6O)=C)CC5)[C@H]31
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 401.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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Metabolism. 2015 Aug;64(8):888-95. doi: 10.1016/j.metabol.2015.04.006. Epub 2015 May 1. PubMed PMID: 25998856. 10: Nejati-Koshki K, Akbarzadeh A, Pourhasan-Moghaddam M, Abhari A, Dariushnejad H. Inhibition of leptin and leptin receptor gene expression by silibinin-curcumin combination. Asian Pac J Cancer Prev. 2014 Jan;14(11):6595-9. PubMed PMID: 24377502. 11: Peelman F, Zabeau L, Moharana K, Savvides SN, Tavernier J. 20 years of leptin: insights into signaling assemblies of the leptin receptor. J Endocrinol. 2014 Oct;223(1):T9-23. doi: 10.1530/JOE-14-0264. Epub 2014 Jul 25. Review. PubMed PMID: 25063754. 12: Alix PM, Guebre-Egziabher F, Soulage CO. Leptin as an uremic toxin: Deleterious role of leptin in chronic kidney disease. Biochimie. 2014 Oct;105:12-21. doi: 10.1016/j.biochi.2014.06.024. Epub 2014 Jul 7. Review. PubMed PMID: 25010649. 13: O'Rahilly S. 20 years of leptin: what we know and what the future holds. J Endocrinol. 2014 Oct;223(1):E1-3. doi: 10.1530/JOE-14-0506. Epub 2014 Aug 20. PubMed PMID: 25143632. 14: Bassi M, Furuya WI, Menani JV, Colombari DS, do Carmo JM, da Silva AA, Hall JE, Moreira TS, Wenker IC, Mulkey DK, Colombari E. Leptin into the ventrolateral medulla facilitates chemorespiratory response in leptin-deficient (ob/ob) mice. Acta Physiol (Oxf). 2014 May;211(1):240-8. doi: 10.1111/apha.12257. Epub 2014 Mar 13. PubMed PMID: 24521430; PubMed Central PMCID: PMC4365783. 15: Salmerón C, Johansson M, Angotzi AR, Rønnestad I, Jönsson E, Björnsson BT, Gutiérrez J, Navarro I, Capilla E. Effects of nutritional status on plasma leptin levels and in vitro regulation of adipocyte leptin expression and secretion in rainbow trout. Gen Comp Endocrinol. 2015 Jan 1;210:114-23. doi: 10.1016/j.ygcen.2014.10.016. Epub 2014 Nov 8. PubMed PMID: 25448259. 16: Turner RT, Kalra SP, Wong CP, Philbrick KA, Lindenmaier LB, Boghossian S, Iwaniec UT. Peripheral leptin regulates bone formation. J Bone Miner Res. 2013 Jan;28(1):22-34. doi: 10.1002/jbmr.1734. PubMed PMID: 22887758; PubMed Central PMCID: PMC3527690. 17: Glendinning JI, Elson AE, Kalik S, Sosa Y, Patterson CM, Myers MG Jr, Munger SD. Taste responsiveness to sweeteners is resistant to elevations in plasma leptin. Chem Senses. 2015 May;40(4):223-31. doi: 10.1093/chemse/bju075. Epub 2015 Mar 4. PubMed PMID: 25740302; PubMed Central PMCID: PMC4398049. 18: Morath V, Bolze F, Schlapschy M, Schneider S, Sedlmayer F, Seyfarth K, Klingenspor M, Skerra A. PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhanced in Vivo Efficacy. Mol Pharm. 2015 May 4;12(5):1431-42. doi: 10.1021/mp5007147. Epub 2015 Apr 10. PubMed PMID: 25811325. 19: Payne GA, Tune JD, Knudson JD. Leptin-induced endothelial dysfunction: a target for therapeutic interventions. Curr Pharm Des. 2014;20(4):603-8. Review. PubMed PMID: 23688011. 20: Barrichon M, Hadi T, Wendremaire M, Ptasinski C, Seigneuric R, Marcion G, Delignette M, Marchet J, Dumas M, Sagot P, Bardou M, Garrido C, Lirussi F. Dose-dependent biphasic leptin-induced proliferation is caused by non-specific IL-6/NF-κB pathway activation in human myometrial cells. Br J Pharmacol. 2015 Jun;172(12):2974-90. doi: 10.1111/bph.13100. Epub 2015 Mar 24. PubMed PMID: 25653112; PubMed Central PMCID: PMC4459017.

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