Efletirizine dihydrochloride | CAS#225367-66-8

MedKoo Cat#: 127179 | Name: Efletirizine dihydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Efletirizine is histamine H1 receptor antagonist.

Chemical Structure

Efletirizine dihydrochloride

CAS#225367-66-8 (dihydrochloride)

Theoretical Analysis

MedKoo Cat#: 127179

Name: Efletirizine dihydrochloride

CAS#: 225367-66-8 (dihydrochloride)

Chemical Formula: C21H26Cl2F2N2O3

Exact Mass: 462.1289

Molecular Weight: 463.35

Elemental Analysis: C, 54.44; H, 5.66; Cl, 15.30; F, 8.20; N, 6.05; O, 10.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

150756-35-7 (free base) 225367-66-8 (dihydrochloride)

Synonym

UCB-28754; UCB28754; UCB 28754; Efletirizine; Efletirizine dihydrochloride

IUPAC/Chemical Name

2-(2-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)ethoxy)acetic acid dihydrochloride

InChi Key

HQWVDUUIOCFXPO-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H24F2N2O3.2ClH/c22-18-5-1-16(2-6-18)21(17-3-7-19(23)8-4-17)25-11-9-24(10-12-25)13-14-28-15-20(26)27;;/h1-8,21H,9-15H2,(H,26,27);2*1H

SMILES Code

Cl.Cl.OC(=O)COCCN1CCN(CC1)C(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 463.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lewis TA, Young MA, Arrington MP, Bayless L, Cai X, Collart P, Eckman JB, Ellis JL, Ene DG, Libertine L, Nicolas JM, Scannell RT, Wels BF, Wenberg K, Wypij DM. Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4. PubMed PMID: 15482930. 2: Salmun LM. Antihistamines in late-phase clinical development for allergic disease. Expert Opin Investig Drugs. 2002 Feb;11(2):259-73. Review. PubMed PMID: 11829715. 3: Coe RA, DeCesare LS, Lee JW. Quantitation of efletirizine in human plasma and urine using automated solid-phase extraction and column-switching high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1999 Jul 9;730(2):239-47. PubMed PMID: 10448959.