Ethylenedicysteine | CAS#14344-48-0 | metabolite of ethylene cysteine dimer

MedKoo Cat#: 596422 | Name: Ethylenedicysteine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ethylenedicysteine is a metabolite of ethylene cysteine dimer (ECD).

Chemical Structure

Ethylenedicysteine

CAS#14344-48-0

Theoretical Analysis

MedKoo Cat#: 596422

Name: Ethylenedicysteine

CAS#: 14344-48-0

Chemical Formula: C8H16N2O4S2

Exact Mass: 268.0551

Molecular Weight: 268.34

Elemental Analysis: C, 35.81; H, 6.01; N, 10.44; O, 23.85; S, 23.89

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Ethylenedicysteine; L,L-ethylenedicysteine;

IUPAC/Chemical Name

(2R,2'R)-2,2'-(ethane-1,2-diylbis(azanediyl))bis(3-mercaptopropanoic acid)

InChi Key

BQHFYSWNHZMMDO-WDSKDSINSA-N

InChi Code

InChI=1S/C8H16N2O4S2/c11-7(12)5(3-15)9-1-2-10-6(4-16)8(13)14/h5-6,9-10,15-16H,1-4H2,(H,11,12)(H,13,14)/t5-,6-/m0/s1

SMILES Code

SC[C@@H](C(O)=O)NCCN[C@@H](CS)C(O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 268.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Dai D, Rollo FD, Bryant J, Kim EE. Noninferiority of (99m)Tc-Ethylenedicysteine-Glucosamine as an Alternative Analogue to (18)F-Fluorodeoxyglucose in the Detection and Staging of Non-Small Cell Lung Cancer. Contrast Media Mol Imaging. 2018 Mar 15;2018:8969714. doi: 10.1155/2018/8969714. eCollection 2018. PubMed PMID: 29736155; PubMed Central PMCID: PMC5875059. 2: Nguyen DL, de Labriolle-Vaylet C, Durand E, Fernandez PX, Bonnin F, Deliu D, Besson FL, Chaumet-Riffaud P. Reproducibility of differential renal function measurement using technetium-99m-ethylenedicysteine dynamic renal scintigraphy: a French prospective multicentre study. Nucl Med Commun. 2018 Jan;39(1):10-15. doi: 10.1097/MNM.0000000000000769. PubMed PMID: 28984816. 3: Takemaru M, Kimura N, Abe Y, Goto M, Matsubara E. The evaluation of brain perfusion SPECT using an easy Z-score imaging system in the mild cognitive impairment subjects with brain amyloid-β deposition. Clin Neurol Neurosurg. 2017 Sep;160:111-115. doi: 10.1016/j.clineuro.2017.06.018. Epub 2017 Jul 5. PubMed PMID: 28715708. 4: Dharmalingam A, Pawar SU, Parelkar SV, Shetye SS, Ghorpade MK, Tilve GH. Tc-99m Ethylenedicysteine and Tc-99m Dimercaptosuccinic Acid Scintigraphy-Comparison of the Two for Detection of Scarring and Differential Cortical Function. Indian J Nucl Med. 2017 Apr-Jun;32(2):93-97. doi: 10.4103/0972-3919.202240. PubMed PMID: 28533635; PubMed Central PMCID: PMC5439197. 5: Kuśmierek J, Bieńkiewicz M, Konecki T, Surma M, Sosnowski M, Płachcińska A. Usefulness of clearance parametric images in detection of regional renal parenchyma dysfunction. Nucl Med Rev Cent East Eur. 2017;20(1):39-44. doi: 10.5603/NMR.a2016.0042. PubMed PMID: 28218346. 6: Pham LV, Bryant JL, Mendez R, Chen J, Tamayo AT, Xu-Monette ZY, Young KH, Manyam GC, Yang D, Medeiros LJ, Ford RJ. Targeting the hexosamine biosynthetic pathway and O-linked N-acetylglucosamine cycling for therapeutic and imaging capabilities in diffuse large B-cell lymphoma. Oncotarget. 2016 Dec 6;7(49):80599-80611. doi: 10.18632/oncotarget.12413. PubMed PMID: 27716624; PubMed Central PMCID: PMC5348344. 7: Ranade R, Basu S. 177Lu-DOTATATE PRRT in Patients with Metastatic Neuroendocrine Tumor and a Single Functioning Kidney: Tolerability and Effect on Renal Function. J Nucl Med Technol. 2016 Jun;44(2):65-9. doi: 10.2967/jnmt.115.168146. Epub 2016 Feb 4. PubMed PMID: 26848166. 8: Pirdamooie S, Shanei A, Moslehi M. Comparison of the Absorbed Dose for (99m)Tc-Diethylenetriaminepentaacetic Acid and (99m)Tc-Ethylenedicysteine Radiopharmaceuticals using Medical Internal Radiation Dosimetry. J Med Signals Sens. 2015 Jul-Sep;5(3):171-5. PubMed PMID: 26284173; PubMed Central PMCID: PMC4528355. 9: Jain TK, Phulsunga RK, Gupta N, Sood A, Bhattacharya A, Mittal BR. Vicarious liver visualization in solitary functioning kidney with technetium-99m ethylenedicysteine renal scintigraphy. Indian J Nucl Med. 2015 Jul-Sep;30(3):272-4. doi: 10.4103/0972-3919.158545. PubMed PMID: 26170576; PubMed Central PMCID: PMC4479922. 10: Jain TK, Basher RK, Mittal BR, Bhatia A, Singh SK, Bhattacharya A. Diagnostic dilemma of urinary leak vs. perirenal abscess on skeletal scintigraphy: The added value of SPECT/CT and renal scintigraphy. Rev Esp Med Nucl Imagen Mol. 2016 Jan-Feb;35(1):48-50. doi: 10.1016/j.remn.2015.05.004. Epub 2015 Jun 29. PubMed PMID: 26139031. 11: Wang F, Fan D, Qian J, Zhang Z, Zhu J, Chen J. Preparation and Biodistribution of Technetium-99m-Labeled Bis- Misonidazole (MISO) as an Imaging Agent for Tumour Hypoxia. Med Chem. 2015;11(7):649-55. PubMed PMID: 25938423. 12: Wrońska-Nofer T, Pisarska A, Trzcinka-Ochocka M, Hałatek T, Stetkiewicz J, Braziewicz J, Nofer JR, Wąsowicz W. Scintigraphic assessment of renal function in steel plant workers occupationally exposed to lead. J Occup Health. 2015;57(2):91-9. doi: 10.1539/joh.14-0115-OA. Epub 2015 Jan 10. PubMed PMID: 25735505. 13: Cichocki P, Surma M, Woźnicki W, Bieńkiewicz M, Płachcińska A, Kuśmierek J. Preliminary assessment of interand intraobserver reproducibility, and normative values of renal mean transit time (MTT) and parenchymal transit time (PTT) for 99mTc-etylenodicysteine. Nucl Med Rev Cent East Eur. 2015;18(1):29-34. doi: 10.5603/NMR.2015.0007. PubMed PMID: 25633514. 14: Kuśmierek J, Pietrzak-Stelmasiak E, Bieńkiewicz M, Woźnicki W, Surma M, Frieske I, Płachcińska A. Diagnostic efficacy of parametric clearance images in detection of renal scars in children with recurrent urinary tract infections. Ann Nucl Med. 2015 Apr;29(3):313-8. doi: 10.1007/s12149-014-0944-4. Epub 2015 Jan 7. PubMed PMID: 25563578. 15: Garg RK, Menon P, Narasimha Rao KL, Arora S, Batra YK. Pyeloplasty for hydronephrosis: Issues of double J stent versus nephrostomy tube as drainage technique. J Indian Assoc Pediatr Surg. 2015 Jan;20(1):32-6. doi: 10.4103/0971-9261.145444. PubMed PMID: 25552829; PubMed Central PMCID: PMC4268754. 16: Angelides S, El-Mashaleh M, Anagnostou M, Howe G, Spencer D, Kumar V, Manolios N. The role of 99mTc-labelled glucosamine (99mTc-ECDG) in the evaluation of rheumatic joint disease: a screening experience. Nucl Med Commun. 2014 Jun;35(6):655-65. doi: 10.1097/MNM.0000000000000096. PubMed PMID: 24594980. 17: Laureano MR, Onishi ET, Bressan RA, Castiglioni ML, Batista IR, Reis MA, Garcia MV, de Andrade AN, de Almeida RR, Garrido GJ, Jackowski AP. Memory networks in tinnitus: a functional brain image study. PLoS One. 2014 Feb 6;9(2):e87839. doi: 10.1371/journal.pone.0087839. eCollection 2014. PubMed PMID: 24516567; PubMed Central PMCID: PMC3916334. 18: Le Ber I, Camuzat A, Guerreiro R, Bouya-Ahmed K, Bras J, Nicolas G, Gabelle A, Didic M, De Septenville A, Millecamps S, Lenglet T, Latouche M, Kabashi E, Campion D, Hannequin D, Hardy J, Brice A; French Clinical and Genetic Research Network on FTD/FTD-ALS. SQSTM1 mutations in French patients with frontotemporal dementia or frontotemporal dementia with amyotrophic lateral sclerosis. JAMA Neurol. 2013 Nov;70(11):1403-10. doi: 10.1001/jamaneurol.2013.3849. PubMed PMID: 24042580; PubMed Central PMCID: PMC4199096. 19: Sohaib M, Rafique A, Saeed S, Afshan A. A comparison of single plasma sample methods to estimate renal clearance using 99mTc-ethylenedicysteine and 99mTc-mercaptoacetyltriglycine. Clin Physiol Funct Imaging. 2013 Sep;33(5):353-8. doi: 10.1111/cpf.12034. Epub 2013 Mar 18. PubMed PMID: 23701132. 20: Tripathi M, Das CJ, Agarwal KK, Khangembam BC, Dhull VS. Spontaneously resolving lower polar ATN in a transplant kidney with dual vascular supply demonstrated on 99mTc EC renography. Clin Nucl Med. 2013 May;38(5):390-1. doi: 10.1097/RLU.0b013e3182868cac. PubMed PMID: 23478851.