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MedKoo Cat#: 592556 | Name: Etilefrine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Etilefrine is a phenylephrine-related beta-1 adrenergic and alpha adrenergic agonist used as a cardiotonic and antihypotensive agent.

Chemical Structure

Etilefrine
Etilefrine
CAS#709-55-7 (free base)

Theoretical Analysis

MedKoo Cat#: 592556

Name: Etilefrine

CAS#: 709-55-7 (free base)

Chemical Formula: C10H15NO2

Exact Mass: 181.1103

Molecular Weight: 181.24

Elemental Analysis: C, 66.27; H, 8.34; N, 7.73; O, 17.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
943-17-9 (HCl) 709-55-7 (free base) 95670-87-4 (S-isomer HCl) 95670-88-5 (R-isomer HCl)
Synonym
Etilefrine; Etilefrin; Effortil; Ethylphenylephrine; Ethyladrianol; Racemic etilefrine; (+-)-Etilefrine; S40032-7; S 40032-7; S40032-7;
IUPAC/Chemical Name
alpha-((Ethylamino)methyl)-m-hydroxybenzyl alcohol
InChi Key
SQVIAVUSQAWMKL-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H15NO2/c1-2-11-7-10(13)8-4-3-5-9(12)6-8/h3-6,10-13H,2,7H2,1H3
SMILES Code
OC1=CC(C(O)CNCC)=CC=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 181.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Muniz G, Hidalgo-Campos J, Valdivia-Tapia MDC, Shaikh N, Carreazo NY. Successful Management of Chylothorax With Etilefrine: Case Report in 2 Pediatric Patients. Pediatrics. 2018 May;141(5). pii: e20163309. doi: 10.1542/peds.2016-3309. PubMed PMID: 29703801. 2: Koga C, Murakami M, Shimizu J, Yasuyama A, Matsumura T, Takata A, Kameda C, Kawabata R, Hirota M, Noura S, Hasegawa J. [A Case of Successful Management of Postoperative Chylous Ascites by Combination Therapy with Octreotide and Etilefrine]. Gan To Kagaku Ryoho. 2018 Mar;45(3):572-574. Japanese. PubMed PMID: 29650942. 3: Bhardwaj R, Vaziri H, Gautam A, Ballesteros E, Karimeddini D, Wu GY. Chylous Ascites: A Review of Pathogenesis, Diagnosis and Treatment. J Clin Transl Hepatol. 2018 Mar 28;6(1):105-113. doi: 10.14218/JCTH.2017.00035. Epub 2017 Dec 4. Review. PubMed PMID: 29577037; PubMed Central PMCID: PMC5863006. 4: Rimayi C, Odusanya D, Weiss JM, de Boer J, Chimuka L. Contaminants of emerging concern in the Hartbeespoort Dam catchment and the uMngeni River estuary 2016 pollution incident, South Africa. Sci Total Environ. 2018 Jun 15;627:1008-1017. doi: 10.1016/j.scitotenv.2018.01.263. Epub 2018 Feb 3. PubMed PMID: 29426120. 5: Ohkura Y, Ueno M, Iizuka T, Udagawa H. Effectiveness of etilefrine regimen for chylothorax after esophagectomy with thoracic duct resection. Esophagus. 2018;15(1):33-38. doi: 10.1007/s10388-017-0592-6. Epub 2017 Sep 14. PubMed PMID: 29308064; PubMed Central PMCID: PMC5742336. 6: Zilker M, Sörgel F, Holzgrabe U. A stability-study of expired ampoules manufactured more than 40 years ago. J Pharm Biomed Anal. 2018 Feb 20;150:318-326. doi: 10.1016/j.jpba.2017.12.019. Epub 2017 Dec 13. PubMed PMID: 29274583. 7: Omar MA, Badr El-Din KM, Salem H, Abdelmageed OH. Novel kinetic spectrophotometric method for estimation of certain biologically active phenolic sympathomimetic drugs in their bulk powders and different pharmaceutical formulations. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Mar 15;193:310-317. doi: 10.1016/j.saa.2017.12.045. Epub 2017 Dec 14. PubMed PMID: 29258026. 8: Omar MA, Badr El-Din KM, Salem H, Abdelmageed OH. Spectrophotometric and spectrofluorimetric methods for determination of certain biologically active phenolic drugs in their bulk powders and different pharmaceutical formulations. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Mar 5;192:108-116. doi: 10.1016/j.saa.2017.10.065. Epub 2017 Nov 8. PubMed PMID: 29127827. 9: Chinegwundoh FI, Smith S, Anie KA. Treatments for priapism in boys and men with sickle cell disease. Cochrane Database Syst Rev. 2017 Sep 19;9:CD004198. doi: 10.1002/14651858.CD004198.pub3. Review. PubMed PMID: 28926088. 10: Tamura T, Kubo N, Yamamoto A, Sakurai K, Toyokawa T, Tanaka H, Muguruma K, Yashiro M, Maeda K, Hirakawa K, Ohira M. Cervical chylous leakage following esophagectomy that was successfully treated by intranodal lipiodol lymphangiography: a case report. BMC Surg. 2017 Feb 28;17(1):20. doi: 10.1186/s12893-017-0218-x. PubMed PMID: 28245822; PubMed Central PMCID: PMC5331703. 11: Badr El-Din KM, Attia TZ. Spectrofluorimetric determination of certain adrenergic agonist drugs in their pure forms and pharmaceutical formulations: Content uniformity test application. Luminescence. 2017 Aug;32(5):706-712. doi: 10.1002/bio.3240. Epub 2016 Nov 29. PubMed PMID: 27900836. 12: Konishi T, Funayama N, Yamamoto T, Nishihara H, Hotta D, Kikuchi K, Yokoyama H, Ohori K. Intraprocedural left ventricular free wall rupture diagnosed by left ventriculogram in a patient with infero-posterior myocardial infarction and severe aortic stenosis. BMC Cardiovasc Disord. 2016 Jun 6;16:126. doi: 10.1186/s12872-016-0302-7. PubMed PMID: 27266264; PubMed Central PMCID: PMC4895822. 13: Ohkura Y, Ueno M, Iizuka T, Haruta S, Tanaka T, Udagawa H. New Combined Medical Treatment With Etilefrine and Octreotide for Chylothorax After Esophagectomy: A Case Report and Review of the Literature. Medicine (Baltimore). 2015 Dec;94(49):e2214. doi: 10.1097/MD.0000000000002214. PubMed PMID: 26656358; PubMed Central PMCID: PMC5008503. 14: Oh H, Li T, An J. Drug Release Properties of a Series of Adenine-Based Metal-Organic Frameworks. Chemistry. 2015 Nov 16;21(47):17010-5. doi: 10.1002/chem.201501560. Epub 2015 Sep 25. PubMed PMID: 26403522. 15: Drugs for hypotension: disproportionate harms with etilefrine and heptaminol. . Prescrire Int. 2015 Jul;24(162):184. PubMed PMID: 26240886. 16: Kremer JJ, Bills AJ, Hanke NJ, Chen H, Meier WA, Osinski MA, Foley CM. Evaluation of cardiovascular changes in dogs administered three positive controls using jacketed external telemetry-blood pressure (JET-BP). J Pharmacol Toxicol Methods. 2015 Sep-Oct;75:27-37. doi: 10.1016/j.vascn.2015.05.008. Epub 2015 May 20. PubMed PMID: 26001324. 17: Hara R, Nagai A, Fujii T, Fukumoto K, Ohira S, Jo Y, Yokoyama T, Miyaji Y. Practical application of color Doppler ultrasonography in patients with ejaculatory dysfunction. Int J Urol. 2015 Jun;22(6):609-11. doi: 10.1111/iju.12754. Epub 2015 Mar 22. PubMed PMID: 25808696. 18: Bender B, Murthy V, Chamberlain RS. The changing management of chylothorax in the modern era. Eur J Cardiothorac Surg. 2016 Jan;49(1):18-24. doi: 10.1093/ejcts/ezv041. Epub 2015 Mar 1. Review. PubMed PMID: 25732972. 19: Zabrzewska B, Chyła A, Bogdan A. Development studies on determination of preservatives decomposition products. Acta Pol Pharm. 2014 Jul-Aug;71(4):563-73. PubMed PMID: 25272883. 20: Niehoff MO, Niggemann B, Sternberg J, Jenkins A, Holbrook M. Measurement of hyper- and hypotension during repeated dose toxicity studies in either freely moving or physically restrained cynomolgus monkeys. J Pharmacol Toxicol Methods. 2014 Nov-Dec;70(3):268-75. doi: 10.1016/j.vascn.2014.09.004. Epub 2014 Sep 16. PubMed PMID: 25219539.

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