MedKoo Cat#: 326925 | Name: Efletirizine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Efletirizine, also known as Ucb-28754, is histamine H1 receptor antagonist potentially for the treatment of allergic rhinitis.

Chemical Structure

Efletirizine
Efletirizine
CAS#150756-35-7 (free base)

Theoretical Analysis

MedKoo Cat#: 326925

Name: Efletirizine

CAS#: 150756-35-7 (free base)

Chemical Formula: C21H24F2N2O3

Exact Mass: 390.1755

Molecular Weight: 390.43

Elemental Analysis: C, 64.60; H, 6.20; F, 9.73; N, 7.18; O, 12.29

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
UCB-28754; UCB28754; UCB 28754; Efletirizine
IUPAC/Chemical Name
(2-(4-(Bis(p-fluorophenyl)methyl)-1-piperazinyl)ethoxy)acetic acid
InChi Key
BAWMMJAUVBLLEE-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H24F2N2O3/c22-18-5-1-16(2-6-18)21(17-3-7-19(23)8-4-17)25-11-9-24(10-12-25)13-14-28-15-20(26)27/h1-8,21H,9-15H2,(H,26,27)
SMILES Code
O=C(O)COCCN1CCN(C(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Related CAS# CAS#150756-35-7 (free) CAS#225367-66-8 (dihydrochloride salt)

Preparing Stock Solutions

The following data is based on the product molecular weight 390.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lewis TA, Young MA, Arrington MP, Bayless L, Cai X, Collart P, Eckman JB, Ellis JL, Ene DG, Libertine L, Nicolas JM, Scannell RT, Wels BF, Wenberg K, Wypij DM. Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4. PubMed PMID: 15482930. 2: Salmun LM. Antihistamines in late-phase clinical development for allergic disease. Expert Opin Investig Drugs. 2002 Feb;11(2):259-73. Review. PubMed PMID: 11829715. 3: Coe RA, DeCesare LS, Lee JW. Quantitation of efletirizine in human plasma and urine using automated solid-phase extraction and column-switching high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl. 1999 Jul 9;730(2):239-47. PubMed PMID: 10448959.