MedKoo Cat#: 127015 | Name: CUR5g
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CUR5g is a potent autophagy inhibitor. CUR5g acts by targeting key regulatory pathways involved in autophagy, such as the inhibition of autophagosome formation or lysosomal degradation, making it a valuable research tool for studying autophagy-related mechanisms. This compound is particularly useful in exploring its implications in cancer research, neurodegenerative diseases, and other conditions where dysregulated autophagy contributes to disease progression. CUR5g’s potency and selectivity make it an essential biochemical reagent in laboratory studies for understanding autophagy and its therapeutic potential.

Chemical Structure

CUR5g
CUR5g
CAS#1370032-20-4

Theoretical Analysis

MedKoo Cat#: 127015

Name: CUR5g

CAS#: 1370032-20-4

Chemical Formula: C22H20N2O2

Exact Mass: 344.1525

Molecular Weight: 344.41

Elemental Analysis: C, 76.72; H, 5.85; N, 8.13; O, 9.29

Price and Availability

Size Price Availability Quantity
10mg USD 90.00 Ready to Ship
25mg USD 150.00 Ready to Ship
50mg USD 250.00 Ready to Ship
100mg USD 450.00 Ready to Ship
200mg USD 750.00 Ready to Ship
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Related CAS #
No Data
Synonym
CUR5g; CUR 5g; CUR-5g
IUPAC/Chemical Name
(E)-3-((1H-indol-3-yl)methylene)-5-((E)-4-hydroxybenzylidene)-1-methylpiperidin-4-one
InChi Key
JMVVTYLZZDOERS-ODPUSEOTSA-N
InChi Code
InChI=1S/C22H20N2O2/c1-24-13-17(10-15-6-8-19(25)9-7-15)22(26)18(14-24)11-16-12-23-21-5-3-2-4-20(16)21/h2-12,23,25H,13-14H2,1H3/b17-10+,18-11+
SMILES Code
O=C1/C(CN(C)C/C1=C\C2=CNC3=C2C=CC=C3)=C/C4=CC=C(O)C=C4
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Autophagy is a cellular process responsible for the degradation and recycling of intracellular components, playing a crucial role in maintaining cellular homeostasis.
Biological target:
In vitro activity:
In vivo activity:
More excitingly, CUR5g showed no obvious toxicity to normal HUVECs in vitro or mice in vivo. CUR5g enhances the cisplatin sensitivity of A549 cells and effectively inhibited autophagy in tumor tissues in vivo. Reference: Chen J, Shen Y, Wu B, Yang P, Sun G, Liu X, Qiang P, Gao Y, Sha F, Li Z, Zhang L. CUR5g, a novel autophagy inhibitor, exhibits potent synergistic anticancer effects with cisplatin against non-small-cell lung cancer. Cell Death Discov. 2022 Oct 31;8(1):435. doi: 10.1038/s41420-022-01217-9. PMID: 36316321; PMCID: PMC9622744.

Preparing Stock Solutions

The following data is based on the product molecular weight 344.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Chen J, Shen Y, Wu B, Yang P, Sun G, Liu X, Qiang P, Gao Y, Sha F, Li Z, Zhang L. CUR5g, a novel autophagy inhibitor, exhibits potent synergistic anticancer effects with cisplatin against non-small-cell lung cancer. Cell Death Discov. 2022 Oct 31;8(1):435. doi: 10.1038/s41420-022-01217-9. PMID: 36316321; PMCID: PMC9622744.