MedKoo Cat#: 565338 | Name: nAS-E
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

nAS-E is an inhibitor of the KIX-KID interaction and CREB-mediated gene transcription.

Chemical Structure

nAS-E
nAS-E
CAS#92-78-4

Theoretical Analysis

MedKoo Cat#: 565338

Name: nAS-E

CAS#: 92-78-4

Chemical Formula: C17H12ClNO2

Exact Mass: 297.0557

Molecular Weight: 297.74

Elemental Analysis: C, 68.58; H, 4.06; Cl, 11.91; N, 4.70; O, 10.75

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Synonym
Naphthol AS-E; nAS-E; nAS E
IUPAC/Chemical Name
N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide
InChi Key
OHAXNCGNVGGWSO-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H12ClNO2/c18-13-5-7-14(8-6-13)19-17(21)15-9-11-3-1-2-4-12(11)10-16(15)20/h1-10,20H,(H,19,21)
SMILES Code
O=C(NC1=CC=C(Cl)C=C1)C2=C(O)C=C3C=CC=CC3=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Naphthol AS-E is a potent and cell-permeable inhibitor of KIX-KID interaction.
In vitro activity:
This study describes the discovery of naphthol AS-E (1) as a cell-permeable small-molecule inhibitor of the KIX–KID interaction by using a novel Renilla luciferase complementation assay. Reference: Chembiochem. 2009 Nov 23;10(17):2721-4. https://pubmed.ncbi.nlm.nih.gov/19810079/
In vivo activity:
In addition, the in vivo effect of nAS-E in protecting against breast cancer-induced osteolysis was evaluated in mice. These results indicated that nAS-E could reverse bone loss induced by MDA-MB-231 tumour. Reference: J Cell Mol Med. 2019 Feb;23(2):1224-1234. https://pubmed.ncbi.nlm.nih.gov/30461194/
Solvent mg/mL mM
Solubility
DMSO 41.7 139.96
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 297.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Yang Q, Tang J, Cao J, Liu F, Fu M, Xue B, Zhou A, Chen S, Liu J, Zhou Y, Shi Y, Peng W, Chen X. SARS-CoV-2 infection activates CREB/CBP in cellular cyclic AMP-dependent pathways. J Med Virol. 2023 Jan;95(1):e28383. doi: 10.1002/jmv.28383. PMID: 36477795; PMCID: PMC9877775. 2. Li BX, Xiao X. Discovery of a small-molecule inhibitor of the KIX-KID interaction. Chembiochem. 2009 Nov 23;10(17):2721-4. doi: 10.1002/cbic.200900552. PMID: 19810079; PMCID: PMC4214275. 3. Kuang Q, Liang Y, Zhuo Y, Cai Z, Jiang F, Xie J, Zheng Y, Zhong W. The ALDOA Metabolism Pathway as a Potential Target for Regulation of Prostate Cancer Proliferation. Onco Targets Ther. 2021 May 24;14:3353-3366. doi: 10.2147/OTT.S290284. PMID: 34079281; PMCID: PMC8163754. 4. Jiang M, Yan Y, Yang K, Liu Z, Qi J, Zhou H, Qian N, Zhou Q, Wang T, Xu X, Xiao X, Deng L. Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis. J Cell Mol Med. 2019 Feb;23(2):1224-1234. doi: 10.1111/jcmm.14024. Epub 2018 Nov 20. PMID: 30461194; PMCID: PMC6349349.
In vitro protocol:
1. Yang Q, Tang J, Cao J, Liu F, Fu M, Xue B, Zhou A, Chen S, Liu J, Zhou Y, Shi Y, Peng W, Chen X. SARS-CoV-2 infection activates CREB/CBP in cellular cyclic AMP-dependent pathways. J Med Virol. 2023 Jan;95(1):e28383. doi: 10.1002/jmv.28383. PMID: 36477795; PMCID: PMC9877775. 2. Li BX, Xiao X. Discovery of a small-molecule inhibitor of the KIX-KID interaction. Chembiochem. 2009 Nov 23;10(17):2721-4. doi: 10.1002/cbic.200900552. PMID: 19810079; PMCID: PMC4214275.
In vivo protocol:
1. Kuang Q, Liang Y, Zhuo Y, Cai Z, Jiang F, Xie J, Zheng Y, Zhong W. The ALDOA Metabolism Pathway as a Potential Target for Regulation of Prostate Cancer Proliferation. Onco Targets Ther. 2021 May 24;14:3353-3366. doi: 10.2147/OTT.S290284. PMID: 34079281; PMCID: PMC8163754. 2. Jiang M, Yan Y, Yang K, Liu Z, Qi J, Zhou H, Qian N, Zhou Q, Wang T, Xu X, Xiao X, Deng L. Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis. J Cell Mol Med. 2019 Feb;23(2):1224-1234. doi: 10.1111/jcmm.14024. Epub 2018 Nov 20. PMID: 30461194; PMCID: PMC6349349.
1: Jiang M, Yan Y, Yang K, Liu Z, Qi J, Zhou H, Qian N, Zhou Q, Wang T, Xu X, Xiao X, Deng L. Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis. J Cell Mol Med. 2019 Feb;23(2):1224-1234. doi: 10.1111/jcmm.14024. Epub 2018 Nov 20. PubMed PMID: 30461194; PubMed Central PMCID: PMC6349349.