MedKoo Cat#: 525734 | Name: Naxagolide HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Naxagolide is a sustained release formulation of a naphthoxazine compound with selective D-2 dopamine receptor agonism. It is a dopamine agonist and an Antiparkinsonian.

Chemical Structure

Naxagolide HCl
Naxagolide HCl
CAS#99705-65-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 525734

Name: Naxagolide HCl

CAS#: 99705-65-4 (HCl)

Chemical Formula: C15H22ClNO2

Exact Mass: 283.1339

Molecular Weight: 283.80

Elemental Analysis: C, 63.48; H, 7.81; Cl, 12.49; N, 4.94; O, 11.28

Price and Availability

Size Price Availability Quantity
2mg USD 325.00 2 Weeks
5mg USD 480.00 2 Weeks
25mg USD 1,110.00 2 Weeks
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Synonym
MK-458; MK458; MK 458; L 647,339; Naxagolide hydrochloride; Naxagolide HCl
IUPAC/Chemical Name
(4aR,10bR)-4-propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol hydrochloride
InChi Key
NNEACMQMRLNNIL-CTHHTMFSSA-N
InChi Code
InChI=1S/C15H21NO2.ClH/c1-2-7-16-8-9-18-15-13-10-12(17)5-3-11(13)4-6-14(15)16;/h3,5,10,14-15,17H,2,4,6-9H2,1H3;1H/t14-,15-;/m1./s1
SMILES Code
OC1=CC2=C(C=C1)CC[C@]3([H])[C@]2([H])OCCN3CCC.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Naxagolide is a sustained release formulation of a naphthoxazine compound with selective D-2 dopamine receptor agonism.
In vitro activity:
TBD
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 283.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1: Narendran R, Slifstein M, Guillin O, Hwang Y, Hwang DR, Scher E, Reeder S, Rabiner E, Laruelle M. Dopamine (D2/3) receptor agonist positron emission tomography radiotracer [11C]-(+)-PHNO is a D3 receptor preferring agonist in vivo. Synapse. 2006 Dec 1;60(7):485-95. PubMed PMID: 16952157. 2: Belluzzi JD, Domino EF, May JM, Bankiewicz KS, McAfee DA. N-0923, a selective dopamine D2 receptor agonist, is efficacious in rat and monkey models of Parkinson's disease. Mov Disord. 1994 Mar;9(2):147-54. PubMed PMID: 7910948.