Naxagolide free base | CAS#88058-88-2 | D2/3 agonist ligand

MedKoo Cat#: 562938 | Name: Naxagolide free base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Naxagolide is a sustained release formulation of a naphthoxazine compound with selective D-2 dopamine receptor agonism. It is a dopamine agonist and an Antiparkinsonian.

Chemical Structure

Naxagolide free base

CAS#88058-88-2 (free base)

Theoretical Analysis

MedKoo Cat#: 562938

Name: Naxagolide free base

CAS#: 88058-88-2 (free base)

Chemical Formula: C15H21NO2

Exact Mass: 247.1572

Molecular Weight: 247.33

Elemental Analysis: C, 72.84; H, 8.56; N, 5.66; O, 12.94

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

99705-65-4 (HCl) 88058-88-2 (free base) 100935-99-7 (S-isomer HCl)

Synonym

Naxagolide; PHNO; Dopazinol; (+)-Propyl-hexahydro-naphtho-oxazin;

IUPAC/Chemical Name

(4aR,10bR)-4-Propyl-2,3,4a,5,6,10b-hexahydrobenzo[h][1,4]benzoxazin-9-ol

InChi Key

JCSREICEMHWFAY-HUUCEWRRSA-N

InChi Code

InChI=1S/C15H21NO2/c1-2-7-16-8-9-18-15-13-10-12(17)5-3-11(13)4-6-14(15)16/h3,5,10,14-15,17H,2,4,6-9H2,1H3/t14-,15-/m1/s1

SMILES Code

OC1=CC=C2CC[C@@]3([H])N(CCC)CCO[C@]3([H])C2=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 247.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Payer D, Balasubramaniam G, Boileau I. What is the role of the D3 receptor in addiction? A mini review of PET studies with [(11)C]-(+)-PHNO. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jul 3;52:4-8. doi: 10.1016/j.pnpbp.2013.08.012. Epub 2013 Aug 30. Review. PubMed PMID: 23999545. 2: Iversen L, Foster AC, Hill RG, Iversen SD, Kemp JA, Leeson PD, Rupniak NM, Saywell K, Tricklebank MD, Williams BJ. Neurotoxin-related research: from the laboratory to the clinic. Ann N Y Acad Sci. 1992 May 11;648:207-18. Review. PubMed PMID: 1353328. 3: Goetz CG, Diederich NJ. Dopaminergic agonists in the treatment of Parkinson's disease. Neurol Clin. 1992 May;10(2):527-40. Review. PubMed PMID: 1350052. 4: Obeso JA, Luquin MR, Vaamonde J, Grandas F, Pastor MA, Artieda J, Martínez-Lage JM. [Continuous dopaminergic stimulation in Parkinson disease]. Neurologia. 1987 Sep-Oct;2(5):227-34. Review. Spanish. PubMed PMID: 2908545.