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MedKoo Cat#: 565064 | Name: TLR7/8 agonist-5d
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TLR7/8 agonist-5d is a TLR7/8 agonist which shows prominent immunostimulatory activities.

Chemical Structure

TLR7/8 agonist-5d
TLR7/8 agonist-5d
CAS#1620278-72-9

Theoretical Analysis

MedKoo Cat#: 565064

Name: TLR7/8 agonist-5d

CAS#: 1620278-72-9

Chemical Formula: C22H27Cl2N5

Exact Mass: 0.0000

Molecular Weight: 432.39

Elemental Analysis: C, 61.11; H, 6.29; Cl, 16.40; N, 16.20

Price and Availability

Size Price Availability Quantity
5mg USD 125.00 Ready to ship
10mg USD 205.00 Ready to ship
25mg USD 450.00 Ready to ship
50mg USD 750.00 Ready to ship
100mg USD 1,250.00 Ready to ship
200mg USD 1,850.00 Ready to ship
500mg USD 3,850.00 Ready to ship
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Related CAS #
No Data
Synonym
TLR7/8 agonist-5d; TLR7/8 agonist5d; TLR7/8 agonist 5d
IUPAC/Chemical Name
2-(4-(Aminomethyl)benzyl)-1-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride
InChi Key
HGYVUJMYZGWKQV-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H25N5.2ClH/c1-2-3-12-27-19(13-15-8-10-16(14-23)11-9-15)26-20-21(27)17-6-4-5-7-18(17)25-22(20)24;;/h4-11H,2-3,12-14,23H2,1H3,(H2,24,25);2*1H
SMILES Code
NC1=NC2=CC=CC=C2C3=C1N=C(CC4=CC=C(CN)C=C4)N3CCCC.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Biological target:
TLR7/8 agonist 1 dihydrochloride is a toll-like receptor TLR7/TLR8 dual-agonistic imidazoquinoline.
In vitro activity:
TBD
In vivo activity:
TBD
Solvent mg/mL mM
Solubility
DMSO 83.3 192.72
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 432.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
TBD
In vitro protocol:
TBD
In vivo protocol:
TBD
1. Shukla NM, Mutz CA, Ukani R, Warshakoon HJ, Moore DS, David SA. Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6384-6. doi: 10.1016/j.bmcl.2010.09.093. Epub 2010 Sep 21. PMID: 20933417; PMCID: PMC2957514. 2. Beesu M, Caruso G, Salyer AC, Khetani KK, Sil D, Weerasinghe M, Tanji H, Ohto U, Shimizu T, David SA. Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity. J Med Chem. 2015 Oct 8;58(19):7833-49. doi: 10.1021/acs.jmedchem.5b01087. Epub 2015 Sep 22. PMID: 26351878; PMCID: PMC4601487.