Quinacrine, aslo known as Mepacrine, is A 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factor-kappaB (NF-kappaB), which may result in the induction of tumor suppressor p53 transcription, the restoration of p53-dependent apoptotic pathways, and tumor cell apoptosis. Continuous NF-kappaB signaling, present in many tumors and in chronic inflammatory processes, promotes the expression of antiapoptotic proteins and cytokines while downregulating the expression of proapoptotic proteins, such as p53.
MedKoo Cat#: 202385
Name: Quinacrine hydrochloride
CAS#: 69-05-6 (HCl)
Chemical Formula: C23H32Cl3N3O
Exact Mass: 0.0000
Molecular Weight: 472.88
Elemental Analysis: C, 58.42; H, 6.82; Cl, 22.49; N, 8.89; O, 3.38
| Solvent | mg/mL | mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.0 | 61.33 | |
| Water | 27.5 | 58.05 | |
| Ethanol | 28.0 | 59.21 |
The following data is based on the product molecular weight 472.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
