RO6806051 is a FABP inhibitor. RO6806051 has been reported to bind to FABP5 and FABP7 with high affinity, showing nanomolar potency in vitro. These FABPs are lipid chaperones involved in the intracellular trafficking of fatty acids and lipid mediators, and they are implicated in various diseases, including neurological disorders, metabolic syndromes, and cancer. In cellular assays, RO6806051 inhibits FABP5/7-mediated signaling, including downstream effects on PPARγ activation, and it modulates endocannabinoid signaling pathways—particularly by affecting anandamide uptake and degradation. Preclinical data suggest RO6806051 may exert neuroprotective and anti-inflammatory effects, making it a potential candidate for diseases like pain, neuroinflammation, or multiple sclerosis
MedKoo Cat#: 126628
Name: RO6806051
CAS#: 1433901-75-7
Chemical Formula: C21H19ClN6
Exact Mass: 390.1360
Molecular Weight: 390.88
Elemental Analysis: C, 64.53; H, 4.90; Cl, 9.07; N, 21.50
The following data is based on the product molecular weight 390.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
