Osaterone acetate | TZP-4238 | CAS#105149-00-6 | steroidal anti-androgen agent

MedKoo Cat#: 126071 | Name: Osaterone acetate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Osaterone acetate is a synthetic steroidal anti-androgen agent.

Chemical Structure

Osaterone acetate

CAS#105149-00-6 (acetate)

Theoretical Analysis

MedKoo Cat#: 126071

Name: Osaterone acetate

CAS#: 105149-00-6 (acetate)

Chemical Formula: C22H27ClO5

Exact Mass: 406.1547

Molecular Weight: 406.90

Elemental Analysis: C, 64.94; H, 6.69; Cl, 8.71; O, 19.66

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

105149-04-0 105149-00-6 (acetate)

Synonym

Osaterone acetate; Osaterone; TZP-4238; TZP4238; TZP 4238;

IUPAC/Chemical Name

(4aR,4bS,6aS,7R,9aS,9bR)-7-acetyl-11-chloro-4a,6a-dimethyl-2-oxo-2,4,4a,4b,5,6,6a,7,8,9,9a,9b-dodecahydroindeno[4,5-h]isochromen-7-yl acetate

InChi Key

KKTIOMQDFOYCEN-OFUYBIASSA-N

InChi Code

InChI=1S/C22H27ClO5/c1-12(24)22(28-13(2)25)8-6-16-14-9-18(23)17-10-19(26)27-11-20(17,3)15(14)5-7-21(16,22)4/h9-10,14-16H,5-8,11H2,1-4H3/t14-,15+,16+,20-,21+,22+/m1/s1

SMILES Code

[H][C@@]12CC[C@](OC(C)=O)(C(C)=O)[C@@]1(C)CC[C@@]3([H])[C@@]2([H])C=C(Cl)C4=CC(=O)OC[C@]34C

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 406.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Albouy M, Sanquer A, Maynard L, Eun HM. Efficacies of osaterone and delmadinone in the treatment of benign prostatic hyperplasia in dogs. Vet Rec. 2008 Aug 9;163(6):179-83. PubMed PMID: 18689779. 2: Tsutsu T, Hori T, Shimizu M, Orima H, Kawakami E, Fukuda S. Regression of prostatic hypertrophy by osaterone acetate in dogs. J Vet Med Sci. 2000 Oct;62(10):1115-9. PubMed PMID: 11073087. 3: Socha P, Zduńczyk S, Tobolski D, Janowski T. The effects of osaterone acetate on clinical signs and prostate volume in dogs with benign prostatic hyperplasia. Pol J Vet Sci. 2018 Dec;21(4):559-566. doi: 10.24425/pjvs.2018.125601. PubMed PMID: 30605276. 4: Tsutsui T, Hori T, Shimizu M, Tatsuzawa C, Kawakami E. Effect of osaterone acetate administration on prostatic regression rate, peripheral blood hormone levels and semen quality in dogs with benign prostatic hypertrophy. J Vet Med Sci. 2001 Apr;63(4):453-6. PubMed PMID: 11346183. 5: Niżański W, Levy X, Ochota M, Pasikowska J. Pharmacological treatment for common prostatic conditions in dogs - benign prostatic hyperplasia and prostatitis: an update. Reprod Domest Anim. 2014 Jun;49 Suppl 2:8-15. doi: 10.1111/rda.12297. Review. PubMed PMID: 24947855. 6: Minato K, Koizumi N, Honma S, Tsukamoto K, Iwamura S. Pharmacokinetics and biliary excretion of osaterone acetate, a new steroidal antiandrogen, in dogs. Drug Metab Dispos. 2002 Feb;30(2):167-72. PubMed PMID: 11792686. 7: Minato K, Honma S, Shinohara Y, Hashimoto T. Metabolism of osaterone acetate in dogs and humans. Steroids. 2005 Aug;70(9):563-72. PubMed PMID: 15923016. 8: Fuse H, Fukumoto S, Sone H, Miyata Y, Saito T, Nakayama K, Takahashi H, Matsumoto T, Ogata E. A new synthetic steroid, osaterone acetate (TZP-4238), increases cortical bone mass and strength by enhancing bone formation in ovariectomized rats. J Bone Miner Res. 1997 Apr;12(4):590-7. PubMed PMID: 9101370. 9: Minato K, Koizumi N, Honma S, Iwamura S, Tsukamoto K. Characterizations of mouse hepatic microsomal monooxygenase catalyzing 11beta-hydroxylation of osaterone acetate. Biochem Pharmacol. 1999 Jul 15;58(2):335-41. PubMed PMID: 10423176. 10: Barbon AR, Ordóñez IA, Haworth P, Glendewar G, Routh A, Pocknell A. DIAGNOSIS AND MANAGEMENT OF BENIGN PROSTATIC HYPERPLASIA IN A PIED TAMARIN (SAGUINUS BICOLOR). J Zoo Wildl Med. 2016 Jun;47(2):609-13. doi: 10.1638/2015-0215.1. PubMed PMID: 27468035.