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MedKoo Cat#: 528604 | Name: Camicinal HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Camicinal, also known as GSK-962040 and KB-77633, is a motilin receptor agonist potentially for the treatment of gastroparesis diabeticorum.

Chemical Structure

Camicinal HCl
Camicinal HCl
CAS#923565-22-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 528604

Name: Camicinal HCl

CAS#: 923565-22-4 (HCl)

Chemical Formula: C25H34ClFN4O

Exact Mass:

Molecular Weight: 461.02

Elemental Analysis: C, 65.13; H, 7.43; Cl, 7.69; F, 4.12; N, 12.15; O, 3.47

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
923565-21-3 (free base) 923565-22-4 (HCl)
Synonym
962040; GSK-962040; KB-77633; GSK962040; KB77633; GSK 962040; KB 77633
IUPAC/Chemical Name
(S)-2-(4-((3-fluorophenyl)amino)piperidin-1-yl)-1-(4-((3-methylpiperazin-1-yl)methyl)phenyl)ethan-1-one hydrochloride
InChi Key
YRXHCLUDHXQHRC-FYZYNONXSA-N
InChi Code
InChI=1S/C25H33FN4O.ClH/c1-19-16-30(14-11-27-19)17-20-5-7-21(8-6-20)25(31)18-29-12-9-23(10-13-29)28-24-4-2-3-22(26)15-24;/h2-8,15,19,23,27-28H,9-14,16-18H2,1H3;1H/t19-;/m0./s1
SMILES Code
C[C@H]1CN(CC2=CC=C(C(CN3CCC(NC4=CC=CC(F)=C4)CC3)=O)C=C2)CCN1.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 461.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hobson R, Farmer AD, Dewit OE, O'Donnell M, Hacquoil K, Robertson D, Barton ME, Dukes GE. The effects of camicinal, a novel motilin agonist, on gastro-esophageal function in healthy humans-a randomized placebo controlled trial. Neurogastroenterol Motil. 2015 Nov;27(11):1629-37. doi: 10.1111/nmo.12663. Epub 2015 Sep 8. PubMed PMID: 26348542. 2: Barshop K, Kuo B. The investigational drug camicinal for the treatment of gastroparesis. Expert Opin Investig Drugs. 2015 Jan;24(1):133-140. Epub 2014 Oct 24. PubMed PMID: 25341626. 3: Zala AV, Walker MM, Talley NJ. Emerging drugs for functional dyspepsia. Expert Opin Emerg Drugs. 2015 Jun;20(2):221-33. doi: 10.1517/14728214.2015.1009827. Epub 2015 Feb 3. Review. PubMed PMID: 25645940. 4: Peeters TL. Gastrointestinal hormones and gut motility. Curr Opin Endocrinol Diabetes Obes. 2015 Feb;22(1):9-13. doi: 10.1097/MED.0000000000000123. Review. PubMed PMID: 25517024. 5: Chapman MJ, Deane AM, O'Connor SL, Nguyen NQ, Fraser RJ, Richards DB, Hacquoil KE, Vasist Johnson LS, Barton ME, Dukes GE. The effect of camicinal (GSK962040), a motilin agonist, on gastric emptying and glucose absorption in feed-intolerant critically ill patients: a randomized, blinded, placebo-controlled, clinical trial. Crit Care. 2016 Aug 1;20(1):232. doi: 10.1186/s13054-016-1420-4. PubMed PMID: 27476581; PubMed Central PMCID: PMC4967996. 6: Camilleri M. Novel Diet, Drugs, and Gastric Interventions for Gastroparesis. Clin Gastroenterol Hepatol. 2016 Aug;14(8):1072-80. doi: 10.1016/j.cgh.2015.12.033. Epub 2016 Jan 4. Review. PubMed PMID: 26762845; PubMed Central PMCID: PMC4931993. 7: Hellström PM, Tack J, Johnson LV, Hacquoil K, Barton ME, Richards DB, Alpers DH, Sanger GJ, Dukes GE. The pharmacodynamics, safety and pharmacokinetics of single doses of the motilin agonist, camicinal, in type 1 diabetes mellitus with slow gastric emptying. Br J Pharmacol. 2016 Jun;173(11):1768-77. doi: 10.1111/bph.13475. Epub 2016 Apr 13. PubMed PMID: 26924243; PubMed Central PMCID: PMC4867742. 8: Sanger GJ. Ghrelin and motilin receptor agonists: time to introduce bias into drug design. Neurogastroenterol Motil. 2014 Feb;26(2):149-55. doi: 10.1111/nmo.12300. Review. PubMed PMID: 24438586. 9: Sanger GJ, Furness JB. Ghrelin and motilin receptors as drug targets for gastrointestinal disorders. Nat Rev Gastroenterol Hepatol. 2016 Jan;13(1):38-48. doi: 10.1038/nrgastro.2015.163. Epub 2015 Sep 22. Review. PubMed PMID: 26392067. 10: Broad J, Góralczyk A, Mannur K, Dukes GE, Sanger GJ. Drugs acting at 5-HT4 , D2 , motilin, and ghrelin receptors differ markedly in how they affect neuromuscular functions in human isolated stomach. Neurogastroenterol Motil. 2014 Jun;26(6):851-61. doi: 10.1111/nmo.12338. Epub 2014 Apr 20. PubMed PMID: 24750304.